The University of Tennessee Graduate School of Medicine, Knoxville

The Department of Surgery

Stacy Stephenson, MD

Assistant Professor
Division of Plastic & Reconstructive Surgery

Research Focus

The Laboratory of Regenerative Medicine focuses on novel approaches for re-growing bone and nerves that have been damaged due to injury. Drs. Stephenson and Masi are particularly interested in healing bone and nerve damage in the arms and legs using carbon-based nanomaterials - structures that directly stimulate the growth of fat-derived adult stem cells to become new bone and nerve cells to repair injuries. They have recently shown that, using these materials, new nerve and bone cells can be generated that might one day be used clinically to repair damaged tissues. The laboratory is also investigating whether new blood vessels can develop within these therapeutic nanomaterials to help improve nerve and bone growth leading to enhanced tissue regeneration. Their long-term goal is to improve care and outcomes of patients by using their own body's fat-derived adult stem cells to repair injuries that cannot be treated by traditional methods.

Current Publications

Hall PT, Bratcher SZ, Stubbs C, Rifkin RE, Grzeskowiak RM, Burton BJ, Greenacre CB, Stephenson SM, Anderson DE, Crouch DL.
Fully implanted prostheses for musculoskeletal limb reconstruction after amputation: An in vivo feasibility study. Annals of Biomedical Engineering. 2020 Oct 9. [Epub ahead of print]

Newby SD, Masi T, Griffin CD, King WJ, Chipman A, Stephenson S, Anderson DE, Biris AS, Bourdo SE, Dhar M.
Functionalized graphene nanoparticles induce human mesenchymal stem cells to express distinct extracellular matrix proteins mediating osteogenesis. International Journal of Nanomedicine. 2020 Apr 15;15:2501-2513. eCollection 2020.

Wofford A, Bow A, Newby S, Brooks S, Rodriguez R, Masi T, Stephenson S, Gotcher J, Anderson DE, Campbell J, Dhar M.
Human fat-derived mesenchymal stem cells xenogenically implanted in a rat model show enhanced new bone formation in maxillary alveolar tooth defects. Stem Cells International. 2020 Feb;2020:8142938.

Yip D, Kirkpatrick A, Xu T, Masi T, Stephenson S, Ripp S, Close D.
Continuous and real-time in vivo autobioluminescent imaging in a mouse model. Methods in Molecular Biology (Clifton, N.J.). 2020;2081:191-201.

Steiner R, Dhar M, Stephenson SM, Newby S, Bow A, Pedersen A, Anderson DE.
Biometric data comparison between Lewis and Sprague Dawley rats. Frontiers in Veterinary Science. 2019 Dec 20;6:469. eCollection 2019. Available in PubMed: Jan. 2020.

Alghazali KM, Newby SD, Nima ZA, Hamzah RN, Watanabe F, Bourdo SE, Masi TJ, Stephenson SM, Anderson DE, Dhar MS, Biris AS.
Functionalized gold nanorod nanocomposite system to modulate differentiation of human mesenchymal stem cells into neural-like progenitors. Scientific Reports. 2017 Nov 30;7(1):16654.

Current Presentations

Alghazali KM, Newby SD, Nima ZA, Hamzah RN, Watanabe F, Bourdo SE, Masi TJ, Stephenson SM, Anderson DE, Dhar M, Biris AS. A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces. Presented at 42nd Society for Biomaterials Annual Meeting and Exposition: The Pinnacle of Biomaterials Innovation and Excellence; 2019 Apr 3-6; Seattle, WA.


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