The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Surgery

Michael D. Karlstad, PhD

Professor
Division of Trauma & Critical Care Surgery
Research

https://orcid.org/0000-0002-3190-8738

Research Focus

Sepsis and Burn Injury, Wound Healing, Nutritional Modulation of the Inflammatory Response, Insulin Resistance in Injury, Trauma and Diabetes, Pancreatic Islet Cell Biology, Diabetes

Research Statement

The Karlstad Lab has devoted a large proportion of its research attention to understanding the inflammation-associated changes that affect pancreatic islets with a primary objective to discover novel therapeutic strategies that could treat or prevent the initiation and progression of type I and II diabetes. The Lab is also working to create new insights into the complex biology of wound healing in normal and diseased states, including obesity, diabetes and sleep disorders.

Education

Undergraduate School
Physiology, BA, Southern Illinois University, Carbondale, IL

Graduate School
Physiology, MS, Michigan State University, East Lansing, MI
Physiology, Ph.D., Loyola University of Chicago, Maywood, IL

Post-Doctoral Fellowship
Nutrition Metabolism Laboratory, Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA

Professional Societies

Shock Society
American Physiological Society

Current Publications

Batdorf HM, Lawes LL, Richardson JT, Burk DH, Dupuy SD, Karlstad MD, Noland RC, Burke SJ, Collier JJ.
NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC matched ICR mice. Am J Physiol Endocrinol Metab. 2023 Aug 23. doi: 10.1152/ajpendo.00033.2023. Online ahead of print.

Martin TM, Burke SJ, Batdorf HM, Burk DH, Ghosh S, Dupuy SD, Karlstad MD, Collier JJ.
ICAM-1 abundance Is increased in pancreatic islets of hyperglycemic female NOD mice and Is rapidly upregulated by NF-κB in pancreatic β-cells. J Immunol. 2022 Jul 18:ji2200065. doi: 10.4049/jimmunol.2200065. Online ahead of print.

Martin TM, Burke SJ, Batdorf HM, Burk DH, Ghosh S, Dupuy SD, Karlstad MD, Collier JJ.
ICAM-1 abundance Is increased in pancreatic islets of hyperglycemic female NOD mice and Is rapidly upregulated by NF-κB in pancreatic β-cells. J Immunol. 2022 Jul 18:ji2200065. doi: 10.4049/jimmunol.2200065. Online ahead of print.

Collier JJ, Batdorf HM, Merrifield KL, Martin TM, White U, Ravussin E, Burk DH, Cooley CR, Karlstad MD, Burke SJ.
Pioglitazone reverses markers of islet beta-cell de-differentiation in db/db mice while modulating expression of genes controlling inflammation and browning in white adipose tissue from insulin-resistant mice and humans. Biomedicines. 2021 Sep 10;9(9):1189.

Collier JJ, Batdorf HM, Merrifield KL, Martin TM, White U, Ravussin E, Burk DH, Cooley CR, Karlstad MD, Burke SJ.
Pioglitazone reverses markers of islet beta-cell de-differentiation in db/db mice while modulating expression of genes controlling inflammation and browning in white adipose tissue from insulin-resistant mice and humans. Biomedicines. 2021 Sep 10;9(9):1189.

Collier JJ, Batdorf HM, Merrifield KL, Martin TM, White U, Ravussin E, Burk DH, Cooley CR, Karlstad MD, Burke SJ.
Pioglitazone reverses markers of islet beta-cell de-differentiation in db/db mice while modulating expression of genes controlling inflammation and browning in white adipose tissue from insulin-resistant mice and humans. Biomedicines. 2021 Sep 10;9(9):1189.

Gray ALH, Antevska A, Link BA, Bogin B, Burke SJ, Dupuy SD, Collier JJ, Levine ZA, Karlstad MD, Do TD.
α-CGRP disrupts amylin fibrillization and regulates insulin secretion: Implications on diabetes and migraine. Chemical Science. 2021 Mar 24. [Epub ahead of print]

Collier JJ, Batdorf HM, Martin TM, Rohli KE, Burk DH, Lu D, Cooley CR, Karlstad MD, Jackson JW, Sparer TE, Zhang J, Mynatt RL, Burke SJ.
Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis. Molecular Metabolism. 2021 Feb;44:101140. Epub 2020 Dec 5.

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