The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Surgery

Deidra J. Mountain, PhD

Professor
Division of Vascular & Endovascular Surgery
Vascular Research Laboratory

https://orcid.org/0000-0002-0217-7462

Research Focus

The Vascular Research Laboratory performs research investigating the development of intimal hyperplasia and restenosis, the most common chronic complications following balloon angioplasty, vascular stenting, and vascular bypass graft surgery. Significant efforts are focused on designing nanoparticles for targeted vascular drug delivery aimed at hyperplasia prevention. The lab's primary objective is the development of therapeutic interventions to increase the success of endovascular procedures and improve long-term vascular surgical outcomes.

Education

Gradaute School
Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN

Post-Doctoral Fellowship
Vascular Biology, University of Tennessee Graduate School of Medicine

Professional Affiliations

American Heart Association
Association for Academic Surgery
Society of Vascular Surgery
Controlled Release Society

Current Publications

Qualls ML, Hagewood H, Lou J, Mattern-Schain SI, Zhang X, Mountain DJ, Best MD.
Bis-boronic acid liposomes for carbohydrate recognition and cellular delivery. Chembiochem. 2022 Aug 31:e202200402. doi: 10.1002/cbic.202200402. Online ahead of print.

Qualls ML, Hagewood H, Lou J, Mattern-Schain SI, Zhang X, Mountain DJ, Best MD.
Bis-boronic acid liposomes for carbohydrate recognition and cellular delivery. Chembiochem. 2022 Aug 31:e202200402. doi: 10.1002/cbic.202200402. Online ahead of print.

Sojka PA, Smith SM, Greenacre CB, Newkirk K, Mountain DJH.
Qualitative investigation of µ- and κ-opioid receptor distribution in the brains of budgerigars (Melopsittacus undulatus). Am J Vet Res. 2022 May 21;83(7):ajvr.21.04.0052. doi: 10.2460/ajvr.21.04.0052.

Sojka PA, Smith SM, Greenacre CB, Newkirk K, Mountain DJH.
Qualitative investigation of µ- and κ-opioid receptor distribution in the brains of budgerigars (Melopsittacus undulatus). Am J Vet Res. 2022 May 21;83(7):ajvr.21.04.0052. doi: 10.2460/ajvr.21.04.0052.

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Fisher RK III, West PC, Mattern-Schain SI, Best MD, Kirkpatrick SS, Dieter RA III, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJH.
Advances in the formulation and assembly of non-cationic lipid nanoparticles for the medical application of gene therapeutics. Nanomaterials (Basel). 2021 Mar;11(3)825.

Buckley MR, Terry PD, Kirkpatrick SS, Arnold JD, McNally MM, Grandas OH, Freeman MB, Goldman MH, Whelan J, Mountain DJ.
Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention. Nutrition Research (New York, N.Y.). 2019 Jun 8;68:34-44.

Current Presentations

West PC, Kinnear TW, Mattern-Schain SI, Kirkpatrick SS, Arnold JD, Buckley MR, Freeman MB, Grandas OH, McNally MM, Mountain DJH. Assembly of Non-Cationic Lipid Nanoparticles for Optimized RNA Drug Payload and Efficacy. Presented at Controlled Release Society 2022 Annual Meeting; 2022 July-11; Montreal, Canada.

McAdams CD, Grimsley LB, West PC, Arnold JD, Buckley RM, Dieter RA, Freeman MB, Grandas OH, McNally MM, Stevens SL. Lipid Nanoparticles Functionalized for Sub-Endothelial Matrix Targeting in Lower Extremity Vessels. Presented at Academic Surgical Congress 2022; 2022 February-1; Orlando, Florida.

Grimsely L, West P, Arnold J, Buckley R, Dieter R, Freeman M, Grandas O, McNally M, Stevens S, Mountain D. Lipid Nanoparticles Functionlized for Sub-Endothelial Matrix Targeting in Lower Extremity Vessels. Presented at Academic Surgical Congress ; 2022 February-1; Orlando, Florida.

McAdams CD, Arnold JD, Buckley MR, Grandas OH, Stevens SL, Mountain DJ, Goldman MH, Freeman MB, McNally MM. Complex endovascular aortic surgery of pararenal and thoracoabdominal aortic aneurysms utilizing laser in situ fenestration technique. Presented at Tennessee Chapter of the American College of Surgeons; 2021 Aug 6-8; Memphis, TN.

McAdams C, Grimsley L, West P, Arnold J, Buckley R, Dieter R, Freeman M, Grandas O, McNally M, Stevens S, Mountain D. Liposomal nanoparticles functionalized for sub-endothelial matrix targeting in human lower extremity vessels. Presented at Tennessee Chapter of the American College of Surgeons; 2021 Aug 6-8; Memphis, TN.

Grimsley L, Fisher R, Dieter R, Arnold J, Buckley R, McNally M, Freeman M, Mountain D, Grandas O. Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular sheer stress. Presented at Tennessee American College of Surgeons Annual Meeting; 2019 Aug 8-11; Chattanooga, TN.

Grimsley LB, Dieter RA, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJH. Dual-ligand modified liposomal nanoparticles multifunctionalized for spatially controlled delivery of gene therapeutics. Presented at Society of Vascular Surgery Vascular Research Initiatives Conference; 2019 May 13; Boston, MA.

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