The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Surgery

Deidra J. Mountain, PhD

Associate Professor
Division of Vascular & Endovascular Surgery
Vascular Research Laboratory

Research Focus

Vascular Wall Biology, Cellular and Molecular Vascular Pathogenesis, Translational Drug Development, Targeted Drug Design

Education

Gradaute School
Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN

Post-Doctoral Fellowship
Vascular Biology, University of Tennessee Graduate School of Medicine

Professional Affiliations

American Heart Association
Association for Academic Surgery
Society of Vascular Surgery
Controlled Release Society

Current Publications

Fisher RK, Mattern-Schain SI, Best MD, Kirkpatrick SS, Freeman MB, Grandas OH, Mountain DJH.
Improving the efficacy of liposome-mediated vascular gene therapy via lipid surface modifications Journal of Surgical Research. 2017 Nov;219:136-144. Epub 2017 Jun 27.

Freeman BM, Univers J, Fisher RK, Kirkpatrick SS, Klein FA, Freeman MB, Mountain DJH, Grandas OH.
Testosterone replacement attenuates intimal hyperplasia development in an androgen deficient model of vascular injury. Journal of Surgical Research. 2017 Jan;207:53-62. Epub 2016 Aug 10.

Current Presentations

Fisher RK, Mattern-Schain SI, Kirkpatrick SS, Best MD, Dieter RA, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJH.. A simple and efficient method for the assembly siRNA-loaded neutral stealth liposomes. Presented at 16th Annual International Nanomedicine & Drug Delivery Symposium; 2018 Sep 21-23; Portland, OR.

Grimsley LB, Fisher RK, Mattern-Schain SI, Dieter RA, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Best MD, Mountain DJ. Cell mimetic liposomal nanocarriers tailored for vascular smooth muscle cell molecular therapeutics. Presented at Tennessee American College of Surgeons Annual Meeting; 2018 Aug 10-12; Nashville, TN.

Fisher RK, Mattern-Schain SI, Kirkpatrick SS, Best MD, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJ. A one-step scalable assembly method for PEGylated liposomes with efficient siRNA-loading and enhanced cellular association. Presented at Controlled Release Society Annual Meeting & Exposition; 2018 Jul 22-25; New York, NY.

Mattern-Schain SI, Fisher RK, Grimsley LB, Kirkpatrick SS, Grandas OH, Beast MD, Mountain DJ. Cell mimetic liposomal nanocarriers tailored for vascular smooth muscle cell molecular therapeutics. Presented at Vascular Research Initiatives Conference; 2018 May 8-12; San Francisco, CA.

Cudnik J, Grimsley L, Fisher R, Kirkpatrick S, Dieter R, Freeman M, Mountain D, Grandas O. Liposomal nanocarriers designed for spatially-controlled targeting under vascular sheer stress. Presented at Southern Association of Vascular Surgery; 2018 Jan 16-20; Scottsdale, AZ.

Cudnik J, West P, Fisher R, Mattern-Schain S, Best M, Kirkpatrick S, Freeman M, Grandas O, Mountain D. Sub-endothelial matrix targeted liposomal nanoparticles for vascular terapeutics. Presented at Society for Vascular Surgery Annual Meeting; 2017 May 31 - Jun 3; San Diego, CA.

Cudnik J, West P, Fisher R, Mattern-Schain S, Best M, Kirkpatrick S, Freeman M, Grandas O, Mountain D. Sub-Endothelial matrix targeted liposomal nanoparticles for vascular therapeutics. Presented at Arteriosclerosis, Thrombosis, and Vascular Biology/Peripheral Vascular Disease; 2017 May 4-6; Minneapolis, MN.

Fisher RK, Mattern-Schain SI, Best MD, Kirkpatrick SS, Freeman MB, Grandas OH, Mountain DJ. Improving the efficacy of liposomal-mediated vascular gene therapy via lipid surface modifications. Presented at 12th Annual Academic Surgical Congress; 2017 Feb 7-9; Las Vegas, NV.

Warner K, Buckley R, Mountain D, Kirkpatrick S, Whelan J, Terry P, Goldman M, Freeman M, Grandas O. Zyfamend+Wholemega fatty acid combinatorial therapy inhibits intimal hyperplasia via the attenuation of M2 macrophage differentiation in a rodent model of vascular injury. Presented at Southern Association for Vascular Surgery; 2017 Jan 18-21; Naples, FL.

Univers J, Mountain D, Freeman B, Fisher R, Kirkpatrick S, Klein F, Freeman M, Grandas O. Urotensin's mechanistic role for development of intimal hyperplasia in androgen deficient males. Presented at Academic Surgical Congress; 2016 Feb 2-4; Jacksonville, FL.

Buckley MR, Mountain DJ, Bools LM, Kirkpatrick SS, Whelan J, Terry P, Freeman MB, Grandas OH. Dietary Zyflamend inhibits intimal hyperplasia development via the attenuation of macrophage infiltration in a rodent model of vascular injury. Presented at Southern Association for Vascular Surgery; 2016 Jan 20-23; Cancun, Mexico.

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