The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Surgery

Michael D. Karlstad, PhD

Professor
Division of Trauma & Critical Care Surgery
Research

https://orcid.org/0000-0002-3190-8738

Research Focus

Sepsis and Burn Injury, Wound Healing, Nutritional Modulation of the Inflammatory Response, Insulin Resistance in Injury, Trauma and Diabetes, Pancreatic Islet Cell Biology, Diabetes

Research Statement

The Karlstad Lab has devoted a large proportion of its research attention to understanding the inflammation-associated changes that affect pancreatic islets with a primary objective to discover novel therapeutic strategies that could treat or prevent the initiation and progression of type I and II diabetes. The Lab is also working to create new insights into the complex biology of wound healing in normal and diseased states, including obesity, diabetes and sleep disorders.

Education

Undergraduate School
Physiology, BA, Southern Illinois University, Carbondale, IL

Graduate School
Physiology, MS, Michigan State University, East Lansing, MI
Physiology, Ph.D., Loyola University of Chicago, Maywood, IL

Post-Doctoral Fellowship
Nutrition Metabolism Laboratory, Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA

Professional Societies

Shock Society
American Physiological Society

Current Publications

Gray ALH, Antevska A, Link BA, Bogin B, Burke SJ, Dupuy SD, Collier JJ, Levine ZA, Karlstad MD, Do TD.
α-CGRP disrupts amylin fibrillization and regulates insulin secretion: Implications on diabetes and migraine. Chemical Science. 2021 Mar 24. [Epub ahead of print]

Collier JJ, Batdorf HM, Martin TM, Rohli KE, Burk DH, Lu D, Cooley CR, Karlstad MD, Jackson JW, Sparer TE, Zhang J, Mynatt RL, Burke SJ.
Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis. Molecular Metabolism. 2021 Feb;44:101140. Epub 2020 Dec 5.

Cooley CR, McLain JM, Dupuy SD, Eder AE, Wintenberg M, Kelly-Wintenberg K, Wintenberg A, Collier JJ, Burke SJ, Karlstad MD.
Indirect, non-thermal atmospheric plasma promotes bacterial killing in vitro and wound disinfection in vivo using monogenic and polygenic models of type 2 diabetes (without adverse metabolic complications). Shock (Augusta, Ga.). 2020 Jun 2. [Epub ahead of print]

Burke SJ, Batdorf HM, Huang TY, Jackson JW, Jones KA, Martin TM, Rohli KE, Karlstad MD, Sparer TE, Burk DH, Campagna SR, Noland RC, Soto PL, Collier JJ.
One week of continuous corticosterone exposure impairs hepatic metabolic flexibility, promotes islet beta-cell proliferation, and reduces physical activity in male C57BL/6 J mice. The Journal of Steroid Biochemistry and Molecular Biology. 2019 Sep 16:105468. [Epub ahead of print]

McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Karlstad MD, Lydic R.
Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. Sleep. 2018 Nov 1;41(11):zsy156. Epub 2018 Aug 11.

Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ.
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet Beta-cell de-differentiation. Molecular Metabolism. 2018 Aug;14:95-107. Epub 2018 Jun 6.

Burke SJ, Batdorf HM, Martin TM, Burk DH, Noland RC, Cooley CR, Karlstad MD, Johnson WD, Collier JJ.
Liquid sucrose consumption promotes obesity and impairs glucose tolerance without altering circulating insulin levels. Obesity (Silver Spring, Md.). 2018 Jul;26(7):1188-1196. Epub 2018 Jun 14.

Collier JJ, Burke SJ, Karlstad MD.
What's new in Shock, November 2017? Shock (Augusta, Ga.). 2017 Nov;48(5):501-503.

Burke SJ, Batdorf HM, Burk DH, Noland RC, Eder AE, Boulos MS, Karlstad MD, Collier JJ.
Db/db mice exhibit features of human type 2 diabetes that are not present in weight-matched C57BL/6J mice fed a western diet. Journal of Diabetes Research. 2017;2017:8503754.

Collier JJ, Sparer TE, Karlstad MD, Burke SJ.
Pancreatic islet inflammation: An emerging role for chemokines. Journal of Molecular Endocrinology. 2017 Jul;59(1):R33-R46. Epub 2017 Apr 18.

Burke SJ, Batdorf HM, Eder AE, Karlstad MD, Burk DH, Noland RC, Floyd ZE, Collier JJ.
Oral corticosterone administration reduces insulitis but promotes insulin resistance and hyperglycemia in male nonobese diabetic mice. The American Journal of Pathology. 2017 Mar;187(3):614-626. Epub 2017 Jan 4.

Burke SJ, Karlstad MD, Eder AE, Regal KM, Lu D, Burk DH, Collier JJ.
Pancreatic beta-cell production of CXCR3 ligands precedes diabetes onset. Biofactors (Oxford, England). 2016 Nov 12;42(6):703-715. Epub 2016 Jun 21.

Burke SJ, Karlstad MD, Collier JJ.
Pancreatic islet responses to metabolic trauma. Shock (Augusta, Ga.). 2016 Sep;46(3):230-8. Epub 2016 Mar 7.

Current Presentations

McLain JM, Cooley CR, Brandi JP, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in obesity-induced type 2 diabetic mouse model. Presented at 41st Annual Conference on Shock; 2018 Jun 9-12; Scottsdale, AZ.

McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in a diabetic mouse. Presented at Society for Neuroscience; 2017 Nov 15-18; Washington, DC.

Alami WH, McLain JM, Wintenberg AL, Wintenberg KD, Collier JJ, Karlstad MD. Effect of atmospheric plasma on wound disinfection in a diabetic animal model. Presented at 40th Annual Conference on Shock; 2017 Jun 3-6; Fort Lauderdale, FL.

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