The Department of Surgery
Michael D. Karlstad, PhD
Professor
Division of Trauma & Critical Care Surgery
Research
https://orcid.org/0000-0002-3190-8738
Research Focus
Sepsis and Burn Injury, Wound Healing, Nutritional Modulation of the Inflammatory Response, Insulin Resistance in Injury, Trauma and Diabetes, Pancreatic Islet Cell Biology, Diabetes
Research Statement
The Karlstad Lab has devoted a large proportion of its research attention to understanding the inflammation-associated changes that affect pancreatic islets with a primary objective to discover novel therapeutic strategies that could treat or prevent the initiation and progression of type I and II diabetes. The Lab is also working to create new insights into the complex biology of wound healing in normal and diseased states, including obesity, diabetes and sleep disorders.
Education
Undergraduate School
Physiology, BA, Southern Illinois University, Carbondale, IL
Graduate School
Physiology, MS, Michigan State University, East Lansing, MI
Physiology, Ph.D., Loyola University of Chicago, Maywood, IL
Post-Doctoral Fellowship
Nutrition Metabolism Laboratory, Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA
Professional Societies
Shock Society
American Physiological Society
Current Publications
Collier JJ, Cothern CR, Ducote MP, Martin TM, Linden MA, Noland RC, Burk DH, Dupuy SD, Karlstad MD, Stadler K, Hirschbeck SS, Do TD, Coldren A, Et al.
Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β-cell maturity. JCI Insight. 2026 Jun 30:e200202. doi: 10.1172/jci.insight.200202. Online ahead of print.
Collier JJ, Wasserfall CH, Brehm MA, Karlstad MD..
Partial remission of type 1 diabetes: Do immunometabolic events define the honeymoon period? Diabetes Obes Metab. 2025 Aug;27(8):4092-4101. doi: 10.1111/dom.16480. Epub 2025 May 28.
Burke SJ, Batdorf HM, Ducote MP, Martin TM, Karlstad MD, Noland RC, Ghosh S, Morrison CD, Collier JJ..
High-protein diet prevents glucocorticoid-induced fat mass accumulation and hyperglycemia. Int J Mol Sci. 2025 Apr 29;26(9):4212. doi: 10.3390/ijms26094212.
Batdorf HM, Lawes LL, Richardson JT, Burk DH, Dupuy SD, Karlstad MD, Noland RC, Burke SJ, Collier JJ.
NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC matched ICR mice. Am J Physiol Endocrinol Metab. 2023 Aug 23. doi: 10.1152/ajpendo.00033.2023. Online ahead of print.