The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Jonathan S. Wall, PhD

Professor
Amyloidosis and Cancer Theranostics Program
Preclinical and Diagnostic Molecular Imaging Laboratory

Research Focus

Preclinical diagnostic imaging of amyloid diseases

Education

Postdoctoral
University of Tennessee Medical Center
Human Immunology & Cancer Program
Knoxville, TN (January 1995- April 1997)

Graduate University of Essex
Department of Chemistry & Biological Chemistry, Colchester, UK (October 1991- December 1994).
Ph.D conferred July 1995

Undergraduate
University of Essex
Department of Biology
Colchester, UK (October 1987-June 1991).
BSc. (Hons.) Biological Sciences, July 1991

Faculty Appointments

Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2009 - present)
Associate Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2003 - June 2009)
Assistant Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (April 1997 - June 2003)
Adjunct Associate Professor, Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, TN (July 2007 - present)
Director, Preclinical and Diagnostic Molecular Imaging Laboratory, University of Tennessee Graduate School of Medicine, Knoxville, TN (11/2005 - present)

Awards and Honors

2011 World Molecular Imaging Congress
San Diego, California
Inveon Image of the Year Award 2011
Translational Image of the Year Award 2011

GSM Faculty Award 2011
GSM Spirit Award
University of Tennessee Graduate School of Medicine, June 2011

Visiting Professor
Amyloid, melanoma and the missing molecular link
University of Uppsala,
Uppsala, Sweden, April 7th 2011

Visiting Professor
Animal imaging in basic, clinical, and translational research
Biochemistry and Molecular Biology Seminar Series,
The Mayo Clinic,
Rochester, MN. March 1st 2011

2010 World Molecular Imaging Congress
Kyoto, Japan
Inveon Image of the Year 2010
Best Presented Image of the Year 2010

Memberships

Member of the American Association of Immunologists (2001-present)
Society of Nuclear Medicine (May 2007-present)
American Association for Laboratory Animal Science (Gold Membership; 2007- present)
International Society of Amyloidosis (Jan 2008- present)
Honorary member Phi Zeta - The Honor Society of Veterinary Medicine (April 2008-present)

Current Publications

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.
Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis. Scientific Reports. 2016 Mar 3;6:22695.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.
The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice. Amyloid. 2015 Dec 24:1-9. [Epub ahead of print]

Kennel SJ, Stuckey A, McWilliams-Koeppen HP, Richey T, Wall JS.
Tc-99m radiolabeled peptide p5 + 14 is an effective probe for SPECT imaging of systemic amyloidosis. Molecular Imaging and Biology. 2015 Nov 16. [Epub ahead of print]

McWilliams-Koeppen HP, Foster JS, Hackenbrack N, Ramirez-Alvarado M, Donohoe D, Williams A, Macy S, Wooliver C, Wortham D, Morrell-Falvey J, Foster CM, Kennel SJ, Wall JS.
Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes. PLoS One. 2015 Sep 22;10(9):e0137716. eCollection 2015.

Osborne DR, Acuff SN, Stuckey A, Wall JS.
A routine PET/CT protocol with streamlined calculations for assessing cardiac amyloidosis using 18F-Florbetapir. Frontiers in Cardiovascular Medicine. Front Cardiovasc Med. 2015 May 2:23.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenbrack N, Kennel SJ, Sparer TE, Wall JS.
Novel heparan sulfate-binding peptides for blocking herpesvirus entry. PLoS One. PLoS One. 2015 May 18;10(5):e0126239.

Lee S, Gregor J, Kennel SJ, Osborne DR, Wall J.
GATE validation of standard dual energy corrections in small animal SPECT-CT. Plos One . 2015 Apr 7;10(4):e0122780.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.
Preclinical validation of the heparin-reactive peptide p5+14 as a molecular imaging agent for visceral amyloidosis. Molecules . 2015 Apr 27;20(5):7657-7682.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.
Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: A positive role for peptide dehalogenation. Peptides. 2014 Oct;60:63-70.

Kennel SJ, Macy S, Wooliver C, Huang Y, Richey T, Heidel E, Wall JS.
Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice. Amyloid. 2014 Mar;21(1):45-53.

McLaughlin MF, Robertson D, Mirzadeh S, Pevsner PH, Wall JS, Kennel SJ.
LnPO4 nanoparticles doped with Ac-225 and sequestered daughters for targeted alpha therapy. Cancer Biotherapy and Radiopharmaceuticals. 2014 Feb;29(1):34-41.

del Pozo-Yauner L, Gonzalez Andrade M, Perez Carreon JI, Wall JS, Sanchez-Lopez R, Rodriguez-Ambriz SL, Fernandez-Velasco DA, Ochoa-Leyva A.
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis. Biochemical and Biophysical Research Communications. 2014 Jan 10;443(2):495-9.

Stout D, Berr SS, LeBlanc A, Kalen JD, Osborne D, Price J, Schiffer W, Kuntner C, Wall J.
Guidance for methods descriptions used in preclinical imaging papers. Molecular Imaging. 2013;12(0):1-15.

Hamill JJ, Sunderland JJ, Leblanc AK, Kojima CJ, Wall J, Martin EB.
Evaluation of CT-based lean-body SUV. Medical Physics. 2013 Sep;40(9):092504.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel E, Gupta N, Lee A, Rader B, Martin EB, Kennel SJ.
A Binding-Site Barrier Affects Imaging Efficiency of High Affinity Amyloid-Reactive Peptide Radiotracers In Vivo. PLoS ONE. 2013 Jun 4;8(6):e66181.

Martin EB, Williams A, Heidel E, Macy S, Kennel SJ, Wall JS.
Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts. Biochemical and Biophysical Research Communications. 2013 Jun 21;436(1):85-9

Rowe JA, Morandi F, Wall JS, Akula M, Kennel SJ, Osborne D, Martin EB, Galyon GD, Long MJ, Stuckey AC, Leblanc AK .
Whole-body biodistribution of 3'-deoxy-3'-[18f]fluorothymidine (18flt) in healthy adult cats. Veterinary Radiology and Ultrasound. 2013 May-Jun;54(3):299-306.

Current Presentations

Wall JS. Imaging amyloidosis. Presented at Amyloidosis: Raising Awareness, Improving Care, and Enhancing New Treatments (Invited Lecture); 2015 Oct 16; Nashville, TN.

Wall JS. Amyloid-targeting-peptides for imaging and therapy. Presented at Visiting Professor, Mayo Clinic (Invited Lecture); 2015 Sep 28 - Oct 2; Rochester, MN.

Martin E, Williams A, Richey T, Stuckey S, Macy S, Wooliver C, Kennel S, Wall J. Characterization of amyloid-reactive peptide, p43—an optimized molecular imaging agent for detection of pancreatic amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Martin E, Richey T, Stuckey A, Macy S, Wooliver C, Osborne D, Kennel S, Wall J. Non-invasive detection of critical cardiac amyloid deposits using a novel peptide, p5R+14. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Martin E, Stuckey A, Williams A, Macy S, Richey T, Uberbacher E, Cheng X, Kennel S. Peptide p5+14 - A synthetic polybasic reagent for imaging amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Williams A, Martin E, Uberbacher E, Cheng X, Kennel S. Serendipitous inhibition of amyloid fibril growth by bi-functional peptides. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ. Characterization of a novel bifunctional “Peptope” for pre-targeting immunotherapy of visceral amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J. Peptides for molecular imaging- It's all good. Presented at 6th Annual Nuclear Medicine Technologists of Tennessee; 2015 Mar 27-29; Franklin, TN.

Kennel SJ, Macy S, Wooliver C, Huang Y, Richey T, Heidel RE, Wall JS. Phagocyte depletion inhibits reactive (AA) amyloid accumulation in amyloid enhancing factor-induced human IL-6 transgenic mice. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Martin EB, Richey T, Stuckey A, Wooliver C, Macy S, Osborne D, Kennel SJ, Wall JS. Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P-component and the novel 125I- p5R+14 peptide. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Macy S, Martin EB, Kennel SJ. Specific accumulation of radiolabeled peptide p5 in cerebral vascular and parenchymal Aß amyloid in mice. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Martin EB, Kennel SJ, Williams A, Richey T, Stuckey A, Wooliver C, Macy S, Wall JS. Characterization of a novel peptide, p43 optimized for renal and pancreatic amyloid detection. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel RE, Martin EB, Kennel SJ. High affinity amyloid-reactive peptide, p5R, binds non-uniformly to large amyloid deposits due to a binding site barrier effect. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Donnell R, Richey T, Stuckey A, Martin EB, Kennel SJ. Heparin-binding peptides, basic fibroblast growth factor and p5R bind to different targets in amyloid-laden mice and controls. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Martin EB, Kennel SJ. Soluble, recombinant, receptor for advanced glycation end-products (RAGE) binds AA amyloid in vivo. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Lee S, Gregor J, Osborne D, Wall J. Dual isotope SPECT imaging of I-123 and I-125. Presented at Institute of Electrical and Electronics Engineers Nuclear Science Symposium; 2013 Oct 27 - Nov 2; Seoul, South Korea.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel RE, Gupta N, Lee A, Rader B, Martin EB, Kennel SJ. A binding-site barrier affects quantitative imaging capabilities of high-affinity amyloid reactive peptide radiotracer p5R. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Wall JS, Richey T, Stuckey A, Wooliver C, Macy S, Osborne D, Martin EB, Kennel SJ. Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Wall JS, Richey T, Stuckey A, Akula M, Kabalka G, Macy S, Martin EB, Kennel SJ. Preliminary evaluation of [18F]SFB- and [18F]FBAM-labeled amyloidophilic peptides in mice with visceral amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Wall JS. The Role of Molecular Imaging and Correlative Studies in the Development of Biologicals for the Treatment and Diagnosis of Amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress, Siemens Industrial Workshop; 2013 Sep 18-21; Savannah, GA.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Osborne D, Wells K, Stuckey A, Wilson S, Wall J, Solomon A. Determination of Cadiac Amyloid Involvement Using 18F-Florbetapir and Dynamic PET. Presented at Society of Nuclear Medicine and Molecular Imaging Annual Meeting; 2013 Jul 26-28; Vancouver, Canada.

Akula M, Collier L, LeBlanc A, Stuckey A, Kennel S, Wall J ,Kabalka G. Automated Synthesis of [18F]FTHA and Its Use in PET/CT Imaging Studies in Domestic Cats. Presented at 20th International Symposium on Radiopharmaceutical Sciences; 2013 May 12-17; Jeju, Korea.

Wall J. Things to Consider in Preclinical Studies Leading to an eIND. Presented at 4th Annual Nuclear Medicine Technologists Meeting; 2013 May 3-5; Gatlinburg, TN.

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