The Department of Medicine

Jonathan S. Wall, PhD

Professor and Assistant Dean for Research
Division of Research
Preclinical and Diagnostic Molecular Imaging Laboratory

https://orcid.org/0000-0002-5516-8578

Research Focus

Dr. Wall is a tenured Professor at the University of Tennessee Graduate School of Medicine where he directs the NIH-funded Amyloidosis and Cancer Theranostics Program focused on the development and translation of biologicals for imaging and therapy of systemic amyloid diseases. Amyloidosis is a family of diseases of increasing recognition, impacting older adults. The amyloid "complex" comprised of clumps of abnormal protein fragments can infiltrate many organs including the heart, nerves and brain. Dr. Wall has over 100 publications, ~13 issued US patents, and has garnered over $10M in grants and research contracts. He and his team have recently started, at UTMC, a new investigator-initiated Phase 1 "first-in-man" clinical trial of a promising new imaging agent for the detection of systemic amyloidosis and they are working to develop novel therapeutic strategies that may help to remove the amyloid complex from the body.

Education

Postdoctoral
University of Tennessee Medical Center
Human Immunology & Cancer Program
Knoxville, TN (January 1995- April 1997)

Graduate University of Essex
Department of Chemistry & Biological Chemistry, Colchester, UK (October 1991- December 1994).
Ph.D conferred July 1995

Undergraduate
University of Essex
Department of Biology
Colchester, UK (October 1987-June 1991).
BSc. (Hons.) Biological Sciences, July 1991

Faculty Appointments

Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2009 - present)
Associate Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2003 - June 2009)
Assistant Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (April 1997 - June 2003)
Adjunct Associate Professor, Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, TN (July 2007 - present)
Director, Preclinical and Diagnostic Molecular Imaging Laboratory, University of Tennessee Graduate School of Medicine, Knoxville, TN (11/2005 - present)

Awards and Honors

2011 World Molecular Imaging Congress
San Diego, California
Inveon Image of the Year Award 2011
Translational Image of the Year Award 2011

GSM Faculty Award 2011
GSM Spirit Award
University of Tennessee Graduate School of Medicine, June 2011

Visiting Professor
Amyloid, melanoma and the missing molecular link
University of Uppsala,
Uppsala, Sweden, April 7th 2011

Visiting Professor
Animal imaging in basic, clinical, and translational research
Biochemistry and Molecular Biology Seminar Series,
The Mayo Clinic,
Rochester, MN. March 1st 2011

2010 World Molecular Imaging Congress
Kyoto, Japan
Inveon Image of the Year 2010
Best Presented Image of the Year 2010

Memberships

Member of the American Association of Immunologists (2001-present)
Society of Nuclear Medicine (May 2007-present)
American Association for Laboratory Animal Science (Gold Membership; 2007- present)
International Society of Amyloidosis (Jan 2008- present)
Honorary member Phi Zeta - The Honor Society of Veterinary Medicine (April 2008-present)

Current Publications

Wall JS, Martin EB, Lands R, Ramchandren R, Stuckey A, Heidel RE, Whittle B, Powell D, Richey T, Williams AD, Foster JS, Guthrie S, Kennel SJ..
Cardiac amyloid detection by PET/CT imaging of iodine ((124)i) evuzamitide ((124)i-p5+14): A phase 1/2 study. JACC Cardiovasc Imaging. 2023 Nov;16(11):1433-1448. doi: 10.1016/j.jcmg.2023.08.009.

Foster JS, Balachandran M, Hancock TJ, Martin EB, Macy S, Wooliver C, Richey T, Stuckey A, Williams AD, Jackson JW, Kennel SJ, Wall JS..
Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion. Front Immunol. 2023 Oct 2;14:1275372. doi: 10.3389/fimmu.2023.1275372. eCollection 2023.

Jackson JW, Foster JS, Martin EB, Macy S, Wooliver C, Balachandran M, Richey T, Heidel RE, Williams AD, Kennel SJ, Wall JS.
Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal. Amyloid. 2023 Sep;30(3):249-260. doi: 10.1080/13506129.2022.2155133. Epub 2022 Dec 21.

Smiley D, Einstein AJ, Chan N, Mintz A, Santana DD, Shetty M, Sekulic M, Goldner K, Wall J, Helmke S, Maurer MS.
Smitcardiac amyloidosis identified by (124)I-AT-01 PET imaging but not cardiac MRI or SPECT (99m)Tc pyrophosphate scintigraphy. J Nucl Cardiol. 2023 May 3. doi: 10.1007/s12350-023-03267-7. Online ahead of print.

Smiley D, Einstein AJ, Chan N, Mintz A, Santana DD, Shetty M, Sekulic M, Goldner K, Wall J, Helmke S, Maurer MS.
Smitcardiac amyloidosis identified by (124)I-AT-01 PET imaging but not cardiac MRI or SPECT (99m)Tc pyrophosphate scintigraphy. J Nucl Cardiol. 2023 May 3. doi: 10.1007/s12350-023-03267-7. Online ahead of print.

Martin EB, Stuckey A, Powell D, Lands R, Whittle B, Wooliver C, Macy S, Foster JS, Guthrie S, Kennel SJ, Wall JS.
Clinical confirmation of pan-amyloid reactivity of radioiodinated peptide (124)I-p5+14 (AT-01) in patients with diverse types of systemic amyloidosis demonstrated by PET/CT imaging. Pharmaceuticals (Basel). 2023 Apr 21;16(4):629. doi: 10.3390/ph16040629.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Mol Imaging Biol. 2022 Jun;24(3):479-488. doi: 10.1007/s11307-021-01681-2. Epub 2021 Nov 16.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Mol Imaging Biol. 2022 Jun;24(3):479-488. doi: 10.1007/s11307-021-01681-2. Epub 2021 Nov 16.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Martin EB, Donnell R, Richey T, Stuckey A, Kennel SJ, Wall JS.
Discrete binding patterns of two heparin-reactive proteins, basic fibroblast growth factor and peptide p5R, in amyloid-laden and healthy mice. Biochemical and Biophysical Research Communications. 2021 May 7;552:136-141.

Current Presentations

Wall J, Heidel RE, Martin EB, Stuckey AC, Whittle BA, Powell D, Lands R, Kennel SJ. Detection and differentiation of cardiac amyloidosis using [124]I-P5+14 PET/CT imaging and the correlation with clinical biomarkers. Presented at American College of Cardiology; 2021 May 15-17; Atlanta, GA.