The University of Tennessee Graduate School of Medicine, Knoxville

The Department of Medicine

Benjamin Shepple, MD, FACC

Clinical Assistant Professor
Division of Cardiology

Research Focus

Dr. Shepple's interest is in next generation cardiac imaging. UTMC is the world's lead enroller in the Aurora clinical trial, a phase-3 evaluation of the radiotracer Flurpiridaz (18F) during PET myocardial perfusion imaging for the detection of hemodynamically significant coronary artery disease as compared to SPECT myocardial perfusion imaging and invasive coronary angiography. Among PET radiotracers, Flurpiridaz has a number of advantageous properties including a longer half-life, better linearity with myocardial blood flow, and reduced positron range. It is the expectation that these properties will result in clinical images with improved accuracy in the non-invasive assessment of coronary artery disease. Further, Flurpiridaz PET imaging exposes patients to significantly less radiation as compared to stand SPECT imaging.


Taylor University, Upland, IN, 2001-2005

Medical School
Indiana University School of Medicine, Indianapolis, IN, 2005-2009

University of Virginia, Charlottesville, VA, 2009-2012

University of Virginia, Charlottesville, VA, Cardiovascular Medicine Fellowship, 2012-2015
Chief Cardiology Fellow, 2014-2015


American Board of Internal Medicine
American Board of Internal Medicine - Cardiovascular Disease

Current Publications

Maddahi J, Agostini D, Bateman TM, Bax JJ, Beanlands RSB, Berman DS, Dorbala S, Garcia EV, Feldman J, Heller GV, Knuuti JM, Martinez-Clark P, Pelletier-Galarneau M, Shepple B, Tamaki N, Tranquart F, Udelson JE..
Flurpiridaz f-18 pet myocardial perfusion imaging in patients with suspected coronary artery disease. J Am Coll Cardiol. 2023 Oct 17;82(16):1598-1610. doi: 10.1016/j.jacc.2023.08.016.

Moodie TR, Taylor J, Shepple B.
A case of cutibacterium acnes pericardial effusion after coronary artery bypass surgery. Cureus. 2023 Aug 7;15(8):e43095. doi: 10.7759/cureus.43095. eCollection 2023 Aug.

Taylor J, Assaf A, Assaf M, Assaf S, Shepple B, Kassira A..
Pulmonary fibroelastoma: A rare cardiac mass presenting with dyspnea. CASE (Phila). 2022 Nov 14;7(2):81-85. doi: 10.1016/ eCollection 2023 Feb.


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