The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Stephen J. Kennel, PhD

Professor
Amyloidosis and Cancer Theranostics Program
Preclinical and Diagnostic Molecular Imaging Laboratory

Education

Graduate School
M.S., Chemistry, University of California, San Diego, CA, 1968

Postgraduate School
Ph.D., Chemistry, University of California, San Diego, CA, 1968

Current Publications

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS.
Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity. PLoS One. 2017 Mar 28;12(3):e0174152. eCollection 2017.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Scott JC, Donnell R, Martin EB, Kennel SJ.
Specific amyloid binding of polybasic peptides in vivo is retained by beta-sheet conformers but lost in the disrupted coil and all D-amino acid variants. Molecular Imaging and Biology. 2017 Feb 22. [Epub ahead of print]

Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM.
Immunoglobulin light chains form an extensive and highly ordered fibril involving the N- and C-termini. ACS Omega. 2017 Feb 28;2(2):712-720. Epub 2017 Feb 27.

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.
Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization. Biochemistry and Biophysics Reports. 2016 Aug 11. [Epub ahead of print]

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.
Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis. Scientific Reports. 2016 Mar 3;6:22695.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.
The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice. Amyloid. 2016;23(1):8-16. Epub 2015 Dec 24.

Kennel SJ, Stuckey A, McWilliams-Koeppen HP, Richey T, Wall JS.
Tc-99m radiolabeled peptide p5 + 14 is an effective probe for SPECT imaging of systemic amyloidosis. Molecular Imaging and Biology. 2015 Nov 16. [Epub ahead of print]

McWilliams-Koeppen HP, Foster JS, Hackenbrack N, Ramirez-Alvarado M, Donohoe D, Williams A, Macy S, Wooliver C, Wortham D, Morrell-Falvey J, Foster CM, Kennel SJ, Wall JS.
Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes. PLoS One. 2015 Sep 22;10(9):e0137716. eCollection 2015.

Suarez-Vega A, Gutierrez-Gil B, Benavides J, Perez V, Tosser-Klopp G, Klopp C, Kennel SJ, Arranz JJ.
Combining GWAS and RNA-Seq approaches for detection of the causal mutation for hereditary junctional epidermolysis bullosa in sheep. PLoS One. PLoS One. 2015 May 8;10(5):e0126416.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenbrack N, Kennel SJ, Sparer TE, Wall JS.
Novel heparan sulfate-binding peptides for blocking herpesvirus entry. PLoS One. PLoS One. 2015 May 18;10(5):e0126239.

Lee S, Gregor J, Kennel SJ, Osborne DR, Wall J.
GATE validation of standard dual energy corrections in small animal SPECT-CT. Plos One . 2015 Apr 7;10(4):e0122780.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.
Preclinical validation of the heparin-reactive peptide p5+14 as a molecular imaging agent for visceral amyloidosis. Molecules . 2015 Apr 27;20(5):7657-7682.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.
Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: A positive role for peptide dehalogenation. Peptides. 2014 Oct;60:63-70.

Current Presentations

Wall JS, Foster JS, Koul R, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Lands R, Hanna W, Kennel SJ. A novel bifunctional peptide-FC-fusion construct for immunotherapy of visceral amyloidosis. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Martin EB, Williams A, Heidel RE, Adams S, Lands R, Hanna W, Kennel SJ, Wall JS. A method to predict the amyloidogenic propensity of light chain proteins by measuring binding to synthetic amyloid fibrils. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Beierle SP, Foster JS, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney FF, Kennel SJ. A bifunctional peptide, “peptope”, for pre-targeting antibody 7D8 to systemic amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ. Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Foster JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Martin EB, Cheng S, Kennel SK. Serendipitous inhibition of Aß and rV lambda 6Wil amyloid fibril growth bi-functional peptides. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS. Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Stuckey A, Osoro M, Williams A, Kennel SJ, Richey T, Wall JS. Further evaluation of bone-seeking agent reactivity with systemic amyloid deposits in vitro and in vivo. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

Stuckey A, Williams A, Martin EB, Richey T, Macy S, Cheng X, Kennel SJ, Wall JS. Preclinical validation and translation of peptide p5+14 as a molecular imaging agent for systemic amyloidoses. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

Osborne D, Stuckey A, Kennel S, Blevins D, Akula M. Fluroaniracetam: Initial biodistribution and characterization of a new brain imaging agent. Presented at Society of Nuclear Medicine and Molecular Imaging Annual Meeting; 2015 Jun 6-10; Baltimore, MD.

Martin E, Williams A, Richey T, Stuckey S, Macy S, Wooliver C, Kennel S, Wall J. Characterization of amyloid-reactive peptide, p43—an optimized molecular imaging agent for detection of pancreatic amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Martin E, Richey T, Stuckey A, Macy S, Wooliver C, Osborne D, Kennel S, Wall J. Non-invasive detection of critical cardiac amyloid deposits using a novel peptide, p5R+14. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Martin E, Stuckey A, Williams A, Macy S, Richey T, Uberbacher E, Cheng X, Kennel S. Peptide p5+14 - A synthetic polybasic reagent for imaging amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Williams A, Martin E, Uberbacher E, Cheng X, Kennel S. Serendipitous inhibition of amyloid fibril growth by bi-functional peptides. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ. Characterization of a novel bifunctional “Peptope” for pre-targeting immunotherapy of visceral amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

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