The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Stephen J. Kennel, PhD

Professor
Division of Research
Preclinical and Diagnostic Molecular Imaging Laboratory

Education

Graduate School
M.S., Chemistry, University of California, San Diego, CA, 1968

Postgraduate School
Ph.D., Chemistry, University of California, San Diego, CA, 1968

Published Book Chapters

Huang L, Huang A, Kennel SJ: Coupling of antibodies with liposomes. In: Liposome Technology: Volume III: Targeted Drug Delivery and Biological Interaction. Boca Raton: CRC Press, 55-62, 2018.

Current Publications

Kennel SJ, Jackson JW, Stuckey A, Richey T, Foster JS, Wall JS..
Preclinical evaluation of Tc-99m p5+14 peptide for spect detection of cardiac amyloidosis. PLoS One. 2024 Apr 5;19(4):e0301756. doi: 10.1371/journal.pone.0301756. eCollection 2024.

Foster JS, Balachandran M, Hancock TJ, Martin EB, Macy S, Wooliver C, Richey T, Stuckey A, Williams AD, Jackson JW, Kennel SJ, Wall JS..
Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion. Front Immunol. 2023 Oct 2;14:1275372. doi: 10.3389/fimmu.2023.1275372. eCollection 2023.

Jackson JW, Foster JS, Martin EB, Macy S, Wooliver C, Balachandran M, Richey T, Heidel RE, Williams AD, Kennel SJ, Wall JS.
Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal. Amyloid. 2023 Sep;30(3):249-260. doi: 10.1080/13506129.2022.2155133. Epub 2022 Dec 21.

Martin EB, Stuckey A, Powell D, Lands R, Whittle B, Wooliver C, Macy S, Foster JS, Guthrie S, Kennel SJ, Wall JS.
Clinical confirmation of pan-amyloid reactivity of radioiodinated peptide (124)I-p5+14 (AT-01) in patients with diverse types of systemic amyloidosis demonstrated by PET/CT imaging. Pharmaceuticals (Basel). 2023 Apr 21;16(4):629. doi: 10.3390/ph16040629.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Mol Imaging Biol. 2022 Jun;24(3):479-488. doi: 10.1007/s11307-021-01681-2. Epub 2021 Nov 16.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Mol Imaging Biol. 2022 Jun;24(3):479-488. doi: 10.1007/s11307-021-01681-2. Epub 2021 Nov 16.

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Wang Z, Huang W, Liu M, Kennel SJ, Wall JS, Cheng X.
Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril. Physical Chemistry Chemical Physics : PCCP. 2021 Sep 22;23(36):20634-20644.

Martin EB, Donnell R, Richey T, Stuckey A, Kennel SJ, Wall JS.
Discrete binding patterns of two heparin-reactive proteins, basic fibroblast growth factor and peptide p5R, in amyloid-laden and healthy mice. Biochemical and Biophysical Research Communications. 2021 May 7;552:136-141.

Current Presentations

Wall J, Heidel RE, Martin EB, Stuckey AC, Whittle BA, Powell D, Lands R, Kennel SJ. Detection and differentiation of cardiac amyloidosis using [124]I-P5+14 PET/CT imaging and the correlation with clinical biomarkers. Presented at American College of Cardiology; 2021 May 15-17; Atlanta, GA.

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