The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Stephen J. Kennel, PhD

Professor
Amyloidosis and Cancer Theranostics Program
Preclinical and Diagnostic Molecular Imaging Laboratory

Education

Graduate School
M.S., Chemistry, University of California, San Diego, CA, 1968

Postgraduate School
Ph.D., Chemistry, University of California, San Diego, CA, 1968

Published Book Chapters

Huang L, Huang A, Kennel SJ: Coupling of antibodies with liposomes. In: Liposome Technology: Volume III: Targeted Drug Delivery and Biological Interaction. Boca Raton: CRC Press, 55-62, 2018.

Current Publications

Rowe JA, Morandi F, Osborne DR, Wall JS, Kennel SJ, Reed RB, LeBlanc AK.
Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[(18) F]fluorothymidine. Anatomia, Histologia, Embryologia. 2018 Oct 23. [Epub ahead of print]

Wall JS, Williams AD, Foster JS, Richey T, Stuckey A, Macy S, Wooliver C, Campagna SR, Tague ED, Farmer AT, Lands RH, Martin EB, Heidel RE, Kennel SJ.
Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy. Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 30. [Epub ahead of print]

Martin EB, Williams AD, Heidel RE, Foster JS, Lands RH, Kennel SJ, Wall JS.
A functional assay to identify amyloidogenic light chains. Amyloid. 2018 Mar 23:1-8.

Martin EB, Williams A, Richey T, Wooliver C, Stuckey A, Foster JS, Kennel SJ, Wall JS.
Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides. Journal of Translational Medicine. 2017 Dec 11;15(1):247. [Epub ahead of print]

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Scott JC, Donnell R, Martin EB, Kennel SJ.
Specific amyloid binding of polybasic peptides in vivo is retained by beta-sheet conformers but lost in the disrupted coil and all D-amino acid variants. Molecular Imaging and Biology. 2017 Oct;19(5):714-722.

Wall JS, Foster JS, Martin EB, Kennel SJ.
Pretargeting immunotherapy: A novel treatment approach for systemic amyloidosis. Pharmaceutical Patent Analyst. 2017 Sep;6(5):215-223. Epub 2017 Aug 21.

Foster JS, Williams AD, Macy S, Richey T, Stuckey A, Wooliver DC, Koul-Tiwari R, Martin EB, Kennel SJ, Wall JS.
A peptide-Fc opsonin with pan-amyloid reactivity. Frontiers in Immunology. 2017 Sep 4;8:1082.

Wall JS, Kennel SJ, Martin EB.
Dual-energy SPECT and the development of peptide p5+14 for imaging amyloidosis. Molecular Imaging. 2017 May;16:1536012117708705.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS.
Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity. PLoS One. 2017 Mar 28;12(3):e0174152. eCollection 2017.

Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM.
Immunoglobulin light chains form an extensive and highly ordered fibril involving the N- and C-termini. ACS Omega. 2017 Feb 28;2(2):712-720. Epub 2017 Feb 27.

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.
Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization. Biochemistry and Biophysics Reports. 2016 Dec;8:89-99. Epub 2016 Aug 11.

Kennel SJ, Stuckey A, McWilliams-Koeppen HP, Richey T, Wall JS.
Tc-99m radiolabeled peptide p5 + 14 is an effective probe for SPECT imaging of systemic amyloidosis. Molecular Imaging and Biology. 2016 Aug;18(4):483-9. 2015 Nov 16.

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.
Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis. Scientific Reports. 2016 Mar 3;6:22695.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.
The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice. Amyloid. 2016;23(1):8-16. Epub 2015 Dec 24.

Current Presentations

Wall JS, Foster JS, Koul R, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Lands R, Hanna W, Kennel SJ. A novel bifunctional peptide-FC-fusion construct for immunotherapy of visceral amyloidosis. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Martin EB, Williams A, Heidel RE, Adams S, Lands R, Hanna W, Kennel SJ, Wall JS. A method to predict the amyloidogenic propensity of light chain proteins by measuring binding to synthetic amyloid fibrils. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Beierle SP, Foster JS, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney FF, Kennel SJ. A bifunctional peptide, “peptope”, for pre-targeting antibody 7D8 to systemic amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ. Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Foster JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Martin EB, Cheng S, Kennel SK. Serendipitous inhibition of Aß and rV lambda 6Wil amyloid fibril growth bi-functional peptides. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS. Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Stuckey A, Osoro M, Williams A, Kennel SJ, Richey T, Wall JS. Further evaluation of bone-seeking agent reactivity with systemic amyloid deposits in vitro and in vivo. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

Stuckey A, Williams A, Martin EB, Richey T, Macy S, Cheng X, Kennel SJ, Wall JS. Preclinical validation and translation of peptide p5+14 as a molecular imaging agent for systemic amyloidoses. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

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