The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Emily Martin, PhD

Assistant Professor
Amyloidosis and Cancer Theranostics Program
Preclinical and Diagnostic Molecular Imaging Laboratory

Research Focus

Amyloid diseases; preclinical imaging; development of amyloid-targeting agents

Education

Graduate
Ph.D. University of Tennessee, Department of Comparative and Experimental Medicine, Knoxville , TN (2010 - 2014)

Undergraduate
B.Sc. University of Tennessee, Department of Biochemistry, Cellular and Molecular Biology, Knoxville, TN (2005 - 2009)

Awards and Honors

2014 International Symposium on Amyloidosis
Best Oral Presentation: "Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P component and the novel 125I-p5R+14 peptide"

2013 World Molecular Imaging Congress
Best Poster Presentation: "Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP"

2012 International Symposium on Amyloidosis
Best Presentation: "The amyloidophilic peptide p5 binds rapidly and stably to visceral amyloid in vivo--A potential radiotracer for PET/CT imaging"

Current Publications

Blancas-Mejia L, Martin EB , Williams A, Wall JS, Ramirez-Alvarado M.
Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients. Biophysical Chemistry. 2017 Sep 1. [Epub ahead of print]

Foster JS, Williams AD, Macy S, Richey T, Stuckey A, Wooliver DC, Koul-Tiwari R, Martin EB, Kennel SJ, Wall JS.
A peptide-Fc opsonin with pan-amyloid reactivity. Frontiers in Immunology. 2017 Sep 4;8:1082.

Wall JS, Foster JS, Martin EB, Kennel SJ.
Pretargeting immunotherapy: A novel treatment approach for systemic amyloidosis. Pharmaceutical Patent Analyst. 2017 Aug 21. [Epub ahead of print]

Wall JS, Kennel SJ, Martin EB.
Dual-energy SPECT and the development of peptide p5+14 for imaging amyloidosis. Molecular Imaging. 2017 May;16:1536012117708705.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS.
Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity. PLoS One. 2017 Mar 28;12(3):e0174152. eCollection 2017.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Scott JC, Donnell R, Martin EB, Kennel SJ.
Specific amyloid binding of polybasic peptides in vivo is retained by beta-sheet conformers but lost in the disrupted coil and all D-amino acid variants. Molecular Imaging and Biology. 2017 Feb 22. [Epub ahead of print]

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.
Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization. Biochemistry and Biophysics Reports. 2016 Dec;8:89-99. Epub 2016 Aug 11.

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.
Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis. Scientific Reports. 2016 Mar 3;6:22695.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.
The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice. Amyloid. 2016;23(1):8-16. Epub 2015 Dec 24.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenbrack N, Kennel SJ, Sparer TE, Wall JS.
Novel heparan sulfate-binding peptides for blocking herpesvirus entry. PLoS One. PLoS One. 2015 May 18;10(5):e0126239.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.
Preclinical validation of the heparin-reactive peptide p5+14 as a molecular imaging agent for visceral amyloidosis. Molecules . 2015 Apr 27;20(5):7657-7682.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.
Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: A positive role for peptide dehalogenation. Peptides. 2014 Oct;60:63-70.

Current Presentations

Wall JS, Foster JS, Koul R, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Lands R, Hanna W, Kennel SJ. A novel bifunctional peptide-FC-fusion construct for immunotherapy of visceral amyloidosis. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Martin EB, Williams A, Heidel RE, Adams S, Lands R, Hanna W, Kennel SJ, Wall JS. A method to predict the amyloidogenic propensity of light chain proteins by measuring binding to synthetic amyloid fibrils. Presented at 58th American Society of Hematology Annual Meeting and Exposition; 2016 Dec 3-6; San Diego, CA.

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney FF, Kennel SJ. A bifunctional peptide, “peptope”, for pre-targeting antibody 7D8 to systemic amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ. Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Foster JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Martin EB, Cheng S, Kennel SK. Serendipitous inhibition of Aß and rV lambda 6Wil amyloid fibril growth bi-functional peptides. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS. Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Stuckey A, Williams A, Martin EB, Richey T, Macy S, Cheng X, Kennel SJ, Wall JS. Preclinical validation and translation of peptide p5+14 as a molecular imaging agent for systemic amyloidoses. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

Martin E, Williams A, Richey T, Stuckey S, Macy S, Wooliver C, Kennel S, Wall J. Characterization of amyloid-reactive peptide, p43—an optimized molecular imaging agent for detection of pancreatic amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Martin E, Richey T, Stuckey A, Macy S, Wooliver C, Osborne D, Kennel S, Wall J. Non-invasive detection of critical cardiac amyloid deposits using a novel peptide, p5R+14. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Martin E, Stuckey A, Williams A, Macy S, Richey T, Uberbacher E, Cheng X, Kennel S. Peptide p5+14 - A synthetic polybasic reagent for imaging amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Williams A, Martin E, Uberbacher E, Cheng X, Kennel S. Serendipitous inhibition of amyloid fibril growth by bi-functional peptides. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ. Characterization of a novel bifunctional “Peptope” for pre-targeting immunotherapy of visceral amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

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