The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Medicine

Emily Martin, PhD

Assistant Professor
Amyloidosis and Cancer Theranostics Program
Preclinical and Diagnostic Molecular Imaging Laboratory

Research Focus

Amyloid diseases; preclinical imaging; development of amyloid-targeting agents

Education

Graduate
Ph.D. University of Tennessee, Department of Comparative and Experimental Medicine, Knoxville , TN (2010 - 2014)

Undergraduate
B.Sc. University of Tennessee, Department of Biochemistry, Cellular and Molecular Biology, Knoxville, TN (2005 - 2009)

Awards and Honors

2014 International Symposium on Amyloidosis
Best Oral Presentation: "Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P component and the novel 125I-p5R+14 peptide"

2013 World Molecular Imaging Congress
Best Poster Presentation: "Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP"

2012 International Symposium on Amyloidosis
Best Presentation: "The amyloidophilic peptide p5 binds rapidly and stably to visceral amyloid in vivo--A potential radiotracer for PET/CT imaging"

Current Publications

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.
Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization. Biochemistry and Biophysics Reports. 2016 Aug 11. [Epub ahead of print]

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.
Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis. Scientific Reports. 2016 Mar 3;6:22695.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.
The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice. Amyloid. 2016;23(1):8-16. Epub 2015 Dec 24.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenbrack N, Kennel SJ, Sparer TE, Wall JS.
Novel heparan sulfate-binding peptides for blocking herpesvirus entry. PLoS One. PLoS One. 2015 May 18;10(5):e0126239.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.
Preclinical validation of the heparin-reactive peptide p5+14 as a molecular imaging agent for visceral amyloidosis. Molecules . 2015 Apr 27;20(5):7657-7682.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.
Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: A positive role for peptide dehalogenation. Peptides. 2014 Oct;60:63-70.

Hamill JJ, Sunderland JJ, Leblanc AK, Kojima CJ, Wall J, Martin EB.
Evaluation of CT-based lean-body SUV. Medical Physics. 2013 Sep;40(9):092504.

Current Presentations

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney FF, Kennel SJ. A bifunctional peptide, “peptope”, for pre-targeting antibody 7D8 to systemic amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ. Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Foster JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS. Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Wall JS, Williams A, Martin EB, Cheng S, Kennel SK. Serendipitous inhibition of Aß and rV lambda 6Wil amyloid fibril growth bi-functional peptides. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS. Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity. Presented at The XVth International Symposium on Amyloidosis (Invited Lecture); 2016 Jul 3-7; Uppsala, Sweden.

Stuckey A, Williams A, Martin EB, Richey T, Macy S, Cheng X, Kennel SJ, Wall JS. Preclinical validation and translation of peptide p5+14 as a molecular imaging agent for systemic amyloidoses. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2016 Jun 11-15; San Diego, CA.

Martin E, Williams A, Richey T, Stuckey S, Macy S, Wooliver C, Kennel S, Wall J. Characterization of amyloid-reactive peptide, p43—an optimized molecular imaging agent for detection of pancreatic amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Martin E, Richey T, Stuckey A, Macy S, Wooliver C, Osborne D, Kennel S, Wall J. Non-invasive detection of critical cardiac amyloid deposits using a novel peptide, p5R+14. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Martin E, Stuckey A, Williams A, Macy S, Richey T, Uberbacher E, Cheng X, Kennel S. Peptide p5+14 - A synthetic polybasic reagent for imaging amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall J, Williams A, Martin E, Uberbacher E, Cheng X, Kennel S. Serendipitous inhibition of amyloid fibril growth by bi-functional peptides. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Wall JS, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ. Characterization of a novel bifunctional “Peptope” for pre-targeting immunotherapy of visceral amyloidosis. Presented at 24th American Peptide Symposium; 2015 Jun 20-25; Orlando, FL.

Martin EB, Richey T, Stuckey A, Wooliver C, Macy S, Osborne D, Kennel SJ, Wall JS. Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P-component and the novel 125I- p5R+14 peptide. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Macy S, Martin EB, Kennel SJ. Specific accumulation of radiolabeled peptide p5 in cerebral vascular and parenchymal Aß amyloid in mice. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Martin EB, Kennel SJ, Williams A, Richey T, Stuckey A, Wooliver C, Macy S, Wall JS. Characterization of a novel peptide, p43 optimized for renal and pancreatic amyloid detection. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Donnell R, Richey T, Stuckey A, Martin EB, Kennel SJ. Heparin-binding peptides, basic fibroblast growth factor and p5R bind to different targets in amyloid-laden mice and controls. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Martin EB, Kennel SJ. Soluble, recombinant, receptor for advanced glycation end-products (RAGE) binds AA amyloid in vivo. Presented at XIVth International Symposium on Amyloidosis; 2014 Apr 27 - May 1; Indianapolis, IN.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel RE, Gupta N, Lee A, Rader B, Martin EB, Kennel SJ. A binding-site barrier affects quantitative imaging capabilities of high-affinity amyloid reactive peptide radiotracer p5R. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Wall JS, Richey T, Stuckey A, Wooliver C, Macy S, Osborne D, Martin EB, Kennel SJ. Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Wall JS, Richey T, Stuckey A, Akula M, Kabalka G, Macy S, Martin EB, Kennel SJ. Preliminary evaluation of [18F]SFB- and [18F]FBAM-labeled amyloidophilic peptides in mice with visceral amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

Martin EB, Richey T, Stuckey A, Heidel RE, Lee A, Rader B, Osborne D, Kennel SJ, Wall JS. Characterization of peptide 125I-p5R+14 as an optimized radiotracer for the in vivo detection of ApoA2c amyloidosis. Presented at The Sixth Annual World Molecular Imaging Congress; 2013 Sep 18-21; Savannah, GA.

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