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Associate Professor
Division of Research
Preclinical and Diagnostic Molecular Imaging Laboratory
https://orcid.org/0000-0003-4993-5782
Amyloid diseases; preclinical imaging; development of amyloid-targeting agents
Graduate
Ph.D. University of Tennessee, Department of Comparative and Experimental Medicine, Knoxville , TN (2010 - 2014)
Undergraduate
B.Sc. University of Tennessee, Department of Biochemistry, Cellular and Molecular Biology, Knoxville, TN (2005 - 2009)
2014 International Symposium on Amyloidosis
Best Oral Presentation: "Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P component and the novel 125I-p5R+14 peptide"
2013 World Molecular Imaging Congress
Best Poster Presentation: "Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP"
2012 International Symposium on Amyloidosis
Best Presentation: "The amyloidophilic peptide p5 binds rapidly and stably to visceral amyloid in vivo--A potential radiotracer for PET/CT imaging"
Hancock TJ, Vlasyuk M, Foster JS, Macy S, Wooliver DC, Balachandran M, Williams AD, Martin EB, Kennel SJ, Heidel ER, Wall JS, Jackson JW..
Neutrophils enhance the clearance of systemic amyloid deposits in a murine amyloidoma model. Front Immunol. 2024 Nov 12;15:1487250. doi: 10.3389/fimmu.2024.1487250. eCollection 2024.
Wall JS, Kennel SJ, Stuckey A,Whittle B, Jackson JW, Williams AD, Hancock T, R. Heidel R, Mehmood M, Kassira A, Lands RH, Watson H, Hung R, Martin EB.
Preliminary observations using 99m-Tc-peptide P5+14 for the detection of AL amyloidosis using SPECT/CT and planar gamma scintigraphic imaging. Blood. 2024,Volume 144, Supplement 1,Page 1910,ISSN 0006-4971,https://doi.org/10.1182/blood-2024-207978.
Wall JS, Kennel SJ, Stuckey A, Richey T, Williams AD, Balachandran M, Hancock T, Jackson JW, Wooliver DC, Macy S, Heidel ER, Lands RH, Martin EB.
Characterization of AT02 bioactivity and an assessment of its potential use as an amyloid-clearing therapeutic for AL amyloidosis. Blood. 2024,Volume 144, Supplement 1,,Page 4641,ISSN 0006-4971, https://doi.org/10.1182/blood-2024-208282.
Martin EB, Stuckey A, Heidel ER, Whittle B, Kassira A, Lands R, Watson H, Raj R, Powell D, Kennel S, Wall JS.
Amyloid imaging with 124I-evuzamitide can detect temporal changes in systemic amyloid load and correlates with echocardiographic parameters in patients with AL or ATTR amyloidosis. Journal of Nuclear Cardiology. 2024,Volume 38, Supplement,101938,ISSN 1071-3581,https://doi.org/10.1016/j.nuclcard.2024.101938.
Heidel ER, Stuckey A, Martin EB, Weisman A, Whittle B, Kennel S, Wall JS.
Differentiation of ATTR amyloidosis based on abdominothoracic organ uptake of 124I-evuzamitide assessed by PET/CT imaging. Journal of Nuclear Cardiology. 2024,Volume 38, Supplement,101939,ISSN 1071-3581,https://doi.org/10.1016/j.nuclcard.2024.101939
Wall J, Martin E, Stuckey A, Whittle B, Jackson J, Williams A, Hancock T, Heidel ER, Mehmood M, Kassira A, Lands R, Watson H, Hung R, Kennel S.
Preliminary evaluation of 99mTc-labeled peptide P5+14 for the detection of cardiopulmonary amyloidosis using SPECT/CT and planar gamma scintigraphic imaging. Journal of Nuclear Medicine. Jun 2024, 65 (supplement 2) 241277
Lands R, Martin EB, Powell D, Stuckey A, Whittle B, Guthrie S, Raj R, Kennel SJ, Wall JS.
Longitudinal PET/CT imaging with iodine ((124)i) evuzamitide reveals organ response to plasma cell immunotherapy in a patient with AL amyloidosis. Amyloid. 2024 Jun;31(2):148-149. doi: 10.1080/13506129.2023.2286427. Epub 2023 Nov 22.
Wall JS, Martin EB, Stuckey A, Whittle B, Jackson JW, Williams A,Hancock T, Heidel ER, Mehmood M, Kassira A, Watson H, Hung R, Kennel S.
Early evaluation of 99mTc-labeled peptide P5+14 for the detection of cardiac amyloidosis using SPECT/CT and planar gamma scintigraphic imaging. Journal of Nuclear Cardiology. 2024,Volume 38, Supplement,102002,ISSN 1071-3581,https://doi.org/10.1016/j.nuclcard.2024.102002.
Wall J, Martin E , Heidel R, Stuckey A, Whittle B, Jackson J, Williams A, Mehmood M, Kanderian A, Rebecca K, Hung R, Lands R, Kennel S.
Detection of amyloid cardiomyopathy in patients with systemic ATTR and AL amyloidosis using SPECT/CT and planar imaging of a technetium-99m-labeled peptide - technetium-99m (99mTc) evuzamitide. Journal of the American College of Cardiology . 2024 Apr, 83 (13_Supplement) 1369.https://doi.org/10.1016/S0735-1097(24)03359-X
Martin E, Stuckey A, Heidel E, Kennel S, Guthrie S, Wall J.
Repeat imaging of patients with AL and ATTR amyloidosis, by 124I-AT-01 PET/CT imaging, reveals dynamic organ-specific changes in amyloid load over time. Journal of Cardiac Failure. 2024, Volume 30, Issue 1,Page 200,ISSN 1071-9164,https://doi.org/10.1016/j.cardfail.2023.10.202.
Lands R, Martin EB, Powell D, Stuckey A, Whittle B, Guthrie S, Raj R, Kennel SJ, Wall JS.
Longitudinal PET/CT imaging with iodine ((124)i) evuzamitide reveals organ response to plasma cell immunotherapy in a patient with AL Amyloidosis. Amyloid. 2023 Nov 22:1-2. doi: 10.1080/13506129.2023.2286427. Online ahead of print.
Wall JS, Martin EB, Lands R, Ramchandren R, Stuckey A, Heidel RE, Whittle B, Powell D, Richey T, Williams AD, Foster JS, Guthrie S, Kennel SJ.
Cardiac amyloid detection by PET/CT imaging of iodine ((124)i) evuzamitide ((124)i-p5+14): A phase 1/2 study. JACC Cardiovasc Imaging. 2023 Nov;16(11):1433-1448. doi: 10.1016/j.jcmg.2023.08.009.
Foster JS, Balachandran M, Hancock TJ, Martin EB, Macy S, Wooliver C, Richey T, Stuckey A, Williams AD, Jackson JW, Kennel SJ, Wall JS.
Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion. Front Immunol. 2023 Oct 2;14:1275372. doi: 10.3389/fimmu.2023.1275372. eCollection 2023.
Jackson JW, Foster JS, Martin EB, Macy S, Wooliver C, Balachandran M, Richey T, Heidel RE, Williams AD, Kennel SJ, Wall JS.
Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal. Amyloid. 2023 Sep;30(3):249-260. doi: 10.1080/13506129.2022.2155133. Epub 2022 Dec 21.
Martin EB, Stuckey A, Powell D, Lands R, Whittle B, Wooliver C, Macy S, Foster JS, Guthrie S, Kennel SJ, Wall JS.
Clinical confirmation of pan-amyloid reactivity of radioiodinated peptide (124)I-p5+14 (AT-01) in patients with diverse types of systemic amyloidosis demonstrated by PET/CT imaging. Pharmaceuticals (Basel). 2023 Apr 21;16(4):629. doi: 10.3390/ph16040629.
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