The Department of Medicine
Emily Martin, PhD
Associate Professor
Division of Research
Preclinical and Diagnostic Molecular Imaging Laboratory
https://orcid.org/0000-0003-4993-5782
Research Focus
Amyloid diseases; preclinical imaging; development of amyloid-targeting agents
Education
Graduate
Ph.D. University of Tennessee, Department of Comparative and Experimental Medicine, Knoxville , TN (2010 - 2014)
Undergraduate
B.Sc. University of Tennessee, Department of Biochemistry, Cellular and Molecular Biology, Knoxville, TN (2005 - 2009)
Awards and Honors
2014 International Symposium on Amyloidosis
Best Oral Presentation: "Detection of cardiac amyloidosis by SPECT/CT imaging using both 125I-serum amyloid P component and the novel 125I-p5R+14 peptide"
2013 World Molecular Imaging Congress
Best Poster Presentation: "Evaluation of SPECT detection of cardiac amyloidosis in mice by using 125I-p5R+14 peptide or 125I-SAP"
2012 International Symposium on Amyloidosis
Best Presentation: "The amyloidophilic peptide p5 binds rapidly and stably to visceral amyloid in vivo--A potential radiotracer for PET/CT imaging"
Current Publications
Lands R, Martin EB, Powell D, Stuckey A, Whittle B, Guthrie S, Raj R, Kennel SJ, Wall JS..
Longitudinal PET/CT imaging with iodine ((124)i) evuzamitide reveals organ response to plasma cell immunotherapy in a patient with AL Amyloidosis. Amyloid. 2023 Nov 22:1-2. doi: 10.1080/13506129.2023.2286427. Online ahead of print.
Wall JS, Martin EB, Lands R, Ramchandren R, Stuckey A, Heidel RE, Whittle B, Powell D, Richey T, Williams AD, Foster JS, Guthrie S, Kennel SJ..
Cardiac amyloid detection by PET/CT imaging of iodine ((124)i) evuzamitide ((124)i-p5+14): A phase 1/2 study. JACC Cardiovasc Imaging. 2023 Nov;16(11):1433-1448. doi: 10.1016/j.jcmg.2023.08.009.
Foster JS, Balachandran M, Hancock TJ, Martin EB, Macy S, Wooliver C, Richey T, Stuckey A, Williams AD, Jackson JW, Kennel SJ, Wall JS..
Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion. Front Immunol. 2023 Oct 2;14:1275372. doi: 10.3389/fimmu.2023.1275372. eCollection 2023.
Jackson JW, Foster JS, Martin EB, Macy S, Wooliver C, Balachandran M, Richey T, Heidel RE, Williams AD, Kennel SJ, Wall JS.
Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a 'don't eat me' signal. Amyloid. 2023 Sep;30(3):249-260. doi: 10.1080/13506129.2022.2155133. Epub 2022 Dec 21.
Martin EB, Stuckey A, Powell D, Lands R, Whittle B, Wooliver C, Macy S, Foster JS, Guthrie S, Kennel SJ, Wall JS.
Clinical confirmation of pan-amyloid reactivity of radioiodinated peptide (124)I-p5+14 (AT-01) in patients with diverse types of systemic amyloidosis demonstrated by PET/CT imaging. Pharmaceuticals (Basel). 2023 Apr 21;16(4):629. doi: 10.3390/ph16040629.
Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]
Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]
Wall JS, Martin EB, Endsley A, Stuckey AC, Williams AD, Powell D, Whittle B, Hall S, Lambeth TR, Julian RR, Stabin M, Lands RH, Kennel SJ.
First in human evaluation and dosimetry calculations for peptide (124)I-p5+14-a novel radiotracer for the detection of systemic amyloidosis using PET/CT imaging. Molecular Imaging and Biology. 2021 Nov 16. [Epub ahead of print]
Martin EB, Donnell R, Richey T, Stuckey A, Kennel SJ, Wall JS.
Discrete binding patterns of two heparin-reactive proteins, basic fibroblast growth factor and peptide p5R, in amyloid-laden and healthy mice. Biochemical and Biophysical Research Communications. 2021 May 7;552:136-141.
Current Presentations
Wall J, Heidel RE, Martin EB, Stuckey AC, Whittle BA, Powell D, Lands R, Kennel SJ. Detection and differentiation of cardiac amyloidosis using [124]I-P5+14 PET/CT imaging and the correlation with clinical biomarkers. Presented at American College of Cardiology; 2021 May 15-17; Atlanta, GA.
Baveja S, Porter J, Martin E, Williams A, Akpa B, Ferris J, Heidel E, Dhand R. Do plasma levels of biomarkers correlate with muscle weakness in patients admitted for medical illnesses? Presented at American Thoracic Society International Conference; 2021 May 14-19; San Diego, CA.
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