The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Radiology

Dustin R. Osborne, PhD

Associate Professor
Molecular Imaging and Translational Research Program

https://orcid.org/0000-0003-1324-5464

Research Focus

The Molecular Imaging and Translational Research program focuses on the development and translation of new molecular imaging and radiochemistry technologies and services. Dr. Osborne and colleagues are currently working on a patented respiratory and head motion correction technology for positron emission tomography (PET) cancer and Alzheimer's imaging. Recently he has developed a novel method for quantitatively testing toxic residual elements in radiopharmaceuticals that may be present as part of the production process. In addition to investigator initiated studies, Dr. Osborne offers clinical trials services and research support for imaging studies, working with partners around the globe on clinically translating new imaging compounds and technologies.

Education

Graduate School
Ph.D., Nuclear Engineering, University of Tennessee, 2006-2011
M.S., Physics: Medical Imaging Physics, University of Tennessee, Knoxville, TN, 2003-2005

Internship
Graduate Research, CITDP, Univeristy of Tennessee Graduate School of Medicine, 2004 - 2006

Certifications

American Board of Nuclear Science in Medicine: Nuclear Medicine Physics & Instrumentation
American Board of Radiology: Board Eligible

Awards and Honors

Selected for and graduated from prestigious Siemens Learning Campus 20-month leadership program
2012 Society of Nuclear Medicine Poster Award Nominee: Honorable Mention
2014 Society of Nuclear Medicine and Molecular Imaging Computer and Instrumentation Council Young Investigator Award

Professional Affiliations

Society of Nuclear Medicine
International Electrical and Electronics Engineers

Current Publications

Blevins DW, Rigney GH, Fang MY, Akula MR, Osborne DR.
Novel methods for the quantification of toxic, residual phase transfer catalyst in fluorine-18 labeled radiotracers. Nuclear Medicine and Biology. 2019 Jul/Aug;74-75:41-48. Epub 2019 Jul 22.

Wong TZ, Benefield T, Masters SC, Kiser JW, Crowley JR, Osborne D, Mawlawi O, Barnwell J, Gupta P, Mintz A, Ryan KA, Perrin SR, Lattanze RK, Townsend DW.
Findings from quality improvement initiatives to assess and improve PET/CT FDG injection infiltration rates in multiple centers. Journal of Nuclear Medicine Technology. 2019 Jun 10. [Epub ahead of print]

Acuff S, Mathotaarachchi S, Zukotynski K, Osborne D, Subramaniam RM.
Clinical and technical considerations for implementing PET brain imaging for dementia. Journal of Nuclear Medicine Technology. 2019 Jun 10. [Epub ahead of print]

Acuff SN, Osborne D.
Evaluation of the use of a modular detector system to collect data in real-time to detect and assess injection quality. Journal of Nuclear Medicine Technology. 2019 Apr 24. [Epub ahead of print]

Rowe JA, Morandi F, Osborne DR, Wall JS, Kennel SJ, Reed RB, LeBlanc AK.
Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[(18) F]fluorothymidine. Anatomia, Histologia, Embryologia. 2019 Jan;48(1):46-52. Epub 2018 Oct 23.

Acuff SN, Jackson AS, Subramaniam RM, Osborne DR.
Practical consideration for integrating PET/CT in radiation therapy planning for patient care. Journal of Nuclear Medicine Technology. 2018 Dec;46(4):343-348. Epub 2018 Aug 3.

Tumpa TR, Acuff SN, Gregor J, Lee S, Hu D, Osborne DR.
Respiratory motion correction using a novel positron emission particle tracking technique: A framework towards individual lesion-based motion correction. Conference Proceedings: IEEE Engineering in Medicine and Biology Society. 2018 Oct;2018:5249-5252. Available in PubMed: Nov 2018.

Akula MR, Blevins D, Kabalka GW, Osborne D.
Synthesis of N-[4-(2'-[18F]fluoroalkyloxybenzoyl)]- and N-[4-methoxy-3[123I]iodobenzoyl]-pyrrolidin-2-ones as potential brain imaging agents. Heterocycles. 2018;97(2):1226-1236. Epub 2018 Jun 12.

Blevins DW, Kabalka GW, Osborne DR, Akula MR.
Effect of added Cu(OTf)2 on the Cu(OTf)2(Py)4-mediated radiofluorination of benzoyl and phthaloylglycinates. Natural Science. 2018 Mar;10(3):83524.

Osborne DR, Acuff SN, Neveu ML, Syed M, Kaman AD, Fu Y.
Feasibility assessment of yttrium-90 liver radioembolization imaging using amplitude-based gated PET/CT. Nuclear Medicine Communications. 2018 Mar;39(3):222-227.

Osborne DR, Kuntner C, Berr S, Stout D.
Guidance for efficient small animal imaging quality control. Molecular Imaging and Biology. 2017 Aug;19(4):485-498.

Osborne DR, Acuff S, Neveu M, Kaman A, Syed M, Fu Y.
90 Y liver radioembolization imaging using amplitude-based gated PET/CT. Clinical Nuclear Medicine. 2017 May;42(5):373-374. Epub 2017 Feb 24.

Current Presentations

Osborne DR, Thakur S, Acuff SN. A retrospective study of physiologic markers to assess radiopharmaceutical infiltration compared to external injection monitoring. Presented at Society of Nuclear Medicine and Molecular Imaging Annual Meeting; 2019 Jun 22-25; Anaheim, CA.

Akula MR, Blevins D, Kabalka G, Osborne DR. An improved synthesis of 4-(4-[F-18]fluorophenyl)piracetam, a PET agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne D. Novel pyridinyl quarternary ammonium salts as precursors of radiofluorination. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 4-(4-[I-123]Iodophenyl)piracetam, a potential SPECT agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 6-[F-18]Fluoropyridine-3-carbaldehyde-O-[4-(2,5-dioxo-2,5-dihydropyrrol-1-yl)butyl and pentyl]oximes, Novel thiol reactive bifunctional agents for peptide labeling. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Acuff S, Whittle B, Green C, Findeiss L, Taylor R, Leschak S, Stephens C, Osborne D. Comparison of interventioonal radiologist and the nuclear medicine technologist radiation exposure when using TheraSphere and SIR-Spheres for liver cancer therapy. Presented at Society of Nuclear Medicine and Molecular imaging; 2017 Jun 10-14; Denver, CO.

Osborne DR. Emerging technologies in PET/CT. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2017 Jun 10-14; Denver, CO.

Osborne DR. Emerging technologies in preclinical and translational imaging. Presented at Society of Nuclear Medicine and Molecular Imaging (Invited Lecture); 2017 Jun 10-14; Denver, CO.

Osborne D, Acuff S, Green C, Taylor R, Findeiss L, Stephens C. Real-time monitoring of yttrium 90 radioembolization dose delivery. Presented at Society of Nuclear Medicine and Molecular Imaging; 2017 Jun 10-14; Denver, CO.

Osborne D, Acuff S, Tumpa T, Hu D. Respiratory motion correction using novel particle tracking techniques. Presented at Society of Nuclear Medicine and Molecular Imaging; 2017 Jun 10-14; Denver, CO.

Fang M, Acuff S, Osborne DR. Use of thermal imaging for respiratory motion correction in PET/CT. Presented at Society of Nuclear Medicine and Molecular Imaging; 2017 Jun 10-14; Denver, CO.

Acuff S, Gaston C, Osborne D. Use of thermal imaging to intervene in brown fat activation prior to PET/CT imaging. Presented at Society of Nuclear Medicine and Molecular imaging; 2017 Jun 10-14; Denver, CO.

Akula M, Blevins D, Kabalka G, Osborne D. Microfluidic synthesis of aniracetam analogues as potential PET brain imaging agents. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Blevins D, Akula M, Kabalka G, Osborne D. Synthesis of 4-(4-[18F]fluorophenylpiracetam, a potential PET agent for Parkinson’s disease. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Akula M, Blevins D, Kabalka G, Osborne D. Improved Microfluidic Synthesis of 1-(2-[18F]fluoroethoxy)-4-[2-{4-(methylsulfonyl) phenyl}cyclopent-1-enyl]benzene, a potential COX-2 inhibitor to characterize solid tumors. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Oler PR, Brown SJ, Campbell PD, Ferrell AS, Fox DR, Osborne DR. Reproducible MRI and radiographic criteria for grading cervical facet and disc degeneration. Presented at International Skeletal Society 43rd Annual Meeting; 2016 Sep 6-9; Paris, France.

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