The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Surgery

Oscar H. Grandas, MD, FACS

Professor
Chief, Division of Transplant Surgery
Division of Vascular & Endovascular Surgery
Division of Transplant Surgery

Clinical Focus

Vascular Surgery, Dialysis Access, Kidney Transplantation

Research Focus

The Vascular Research Laboratory performs research investigating the development of intimal hyperplasia and restenosis, the most common chronic complications following balloon angioplasty, vascular stenting, and vascular bypass graft surgery. Significant efforts are focused on designing nanoparticles for targeted vascular drug delivery aimed at hyperplasia prevention. The lab's primary objective is the development of therapeutic interventions to increase the success of endovascular procedures and improve long-term vascular surgical outcomes.

Education

Postgraduate
Master's of Business Administration, Heller School of Management, Brandeis University, Boston, MA

Medical School
Universidad Nacional de Colombia, Bogota, Colombia

Internship
General Surgery, Washington Hospital Center, Washington, DC

Residency
General Surgery, University of Tennessee Graduate School of Medicine

Fellowship
Vascular Surgery, University of Tennessee Graduate School of Medicine
Transplant Surgery, Washington Hospital Center, Washington, DC

Certifications

American Board of Surgery
American Board of Surgery/Vascular Surgery

Professional Affiliations

American College of Surgeons
Southeastern Surgical Congress
The Transplant Society
Association for Academic Surgery
American Society of Transplantation
The Southern Association for Vascular Surgery
Tennessee Transplant Society
American Society of Transplant Surgeons
American College of Physician Executives
Society of Vascular Surgeons

Current Publications

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Grimsley LB, West PC, McAdams CD, Bush CA, Kirkpatrick SS, Arnold JD, Buckley MR, Dieter RA, Freeman MB, McNally MM, Stevens SL, Grandas OH, Mountain DJH.
Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular flow conditions. Pharmaceutics. 2021 Oct 31;13(11):1816. Available in PubMed: Nov 2021.

Fisher RK III, West PC, Mattern-Schain SI, Best MD, Kirkpatrick SS, Dieter RA III, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJH.
Advances in the formulation and assembly of non-cationic lipid nanoparticles for the medical application of gene therapeutics. Nanomaterials (Basel). 2021 Mar;11(3)825.

Buckley M, Carlson E, Heidel E, McNally M, Hodge A, Fahmy M, Arnold J, Grandas O, Freeman M.
Double mandibular osteotomy for access to high-carotid pathology. Annals of Vascular Surgery. 2020 Aug 28:S0890-5096(20)30773-1. [Epub ahead of print]

Buckley MR, Terry PD, Kirkpatrick SS, Arnold JD, McNally MM, Grandas OH, Freeman MB, Goldman MH, Whelan J, Mountain DJ.
Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention. Nutrition Research (New York, N.Y.). 2019 Jun 8;68:34-44.

Current Presentations

Kinnear T, McAdams C, West PC, Matter-Schain S, Kirkpatrick S, Arnold J, Buckley RM, Freeman M, Grandas O, McNally M, Stevens S, Mountain DJ. Multi-functionalized lipid nanoparticles for targeted delivery in an in vivo model of vascular injury Presented at 18th Annual Academic Surgical Congress; 2023 Feburary - 7; Houston.

Fowler BB, Oliva CD, Arnold JD, Buckley MR, Grandas OH, Goldman MH, Stevens SL, Freeman MB, McNally MM. Outcomes of Critically Ill COVID Positive Patients with Cardiovascular Events. Presented at Tennessee Chapter of the American College of Surgeons; 2022 August-11; Nashville, Tennessee.

West PC, Kinnear TW, Mattern-Schain SI, Kirkpatrick SS, Arnold JD, Buckley MR, Freeman MB, Grandas OH, McNally MM, Mountain DJH. Assembly of Non-Cationic Lipid Nanoparticles for Optimized RNA Drug Payload and Efficacy. Presented at Controlled Release Society 2022 Annual Meeting; 2022 July-11; Montreal, Canada.

McAdams CD, Grimsley LB, West PC, Arnold JD, Buckley RM, Dieter RA, Freeman MB, Grandas OH, McNally MM, Stevens SL. Lipid Nanoparticles Functionalized for Sub-Endothelial Matrix Targeting in Lower Extremity Vessels. Presented at Academic Surgical Congress 2022; 2022 February-1; Orlando, Florida.

Grimsely L, West P, Arnold J, Buckley R, Dieter R, Freeman M, Grandas O, McNally M, Stevens S, Mountain D. Lipid Nanoparticles Functionlized for Sub-Endothelial Matrix Targeting in Lower Extremity Vessels. Presented at Academic Surgical Congress ; 2022 February-1; Orlando, Florida.

McAdams CD, Arnold JD, Buckley MR, Grandas OH, Stevens SL, Mountain DJ, Goldman MH, Freeman MB, McNally MM. Complex endovascular aortic surgery of pararenal and thoracoabdominal aortic aneurysms utilizing laser in situ fenestration technique. Presented at Tennessee Chapter of the American College of Surgeons; 2021 Aug 6-8; Memphis, TN.

McAdams C, Grimsley L, West P, Arnold J, Buckley R, Dieter R, Freeman M, Grandas O, McNally M, Stevens S, Mountain D. Liposomal nanoparticles functionalized for sub-endothelial matrix targeting in human lower extremity vessels. Presented at Tennessee Chapter of the American College of Surgeons; 2021 Aug 6-8; Memphis, TN.

Powell BC, Foulke EE, Buckley MR, Arnold JD, Grandas OH, Stevens SL, Goldman MH, Freeman MB, McNally MM. Increased amputation rates in COVID negative patients during the COVID pandemic. Presented at Society for Clinical Vascular Surgery 48th Annual Symposium; 2021 Mar 13-17; Virtual.

Hodge AS, Fahmy MD, McNally MM, Arnold JA, Grandas OH, Stevens SL, Goldman MH, Carlson ER, Freeman MB, Buckley MR. Clinical outcomes of double manibular osteotomy for exposure of skull based carotid artery pathology. Presented at Vascular and Endovascular Surgery Society; 2020 Jan 30 - Feb 2; Steamboat Springs, CO.

Grimsley L, Fisher R, Dieter R, Arnold J, Buckley R, McNally M, Freeman M, Mountain D, Grandas O. Liposomal nanocarriers designed for sub-endothelial matrix targeting under vascular sheer stress. Presented at Tennessee American College of Surgeons Annual Meeting; 2019 Aug 8-11; Chattanooga, TN.

Grimsley LB, Dieter RA, Arnold JD, Buckley MR, McNally MM, Freeman MB, Grandas OH, Mountain DJH. Dual-ligand modified liposomal nanoparticles multifunctionalized for spatially controlled delivery of gene therapeutics. Presented at Society of Vascular Surgery Vascular Research Initiatives Conference; 2019 May 13; Boston, MA.

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