Jonathan S. Wall, PhD
Director, Preclinical and Diagnostic Molecular Imaging
Laboratory
Professor, Department of Medicine
Human Immunology and Cancer Program
Complete Curriculum Vitae (Prepared Nov. 8, 2011)
Education
Postdoctoral
University of Tennessee Medical Center
Human Immunology & Cancer Program
Knoxville, TN (January 1995- April 1997)
Graduate
University of Essex
Department of Chemistry & Biological Chemistry, Colchester, UK (October 1991- December 1994).
Ph.D conferred July 1995
Undergraduate
University of Essex
Department of Biology
Colchester, UK (October 1987-June 1991).
BSc. (Hons.) Biological Sciences, July 1991
Faculty Appointments
Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2009 - present)
Associate Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2003 – June 2009)
Assistant Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (April 1997- June 2003)
Adjunct Associate Professor, Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, TN (July 2007 – present)
Director, Preclinical and Diagnostic Molecular Imaging Laboratory, University of Tennessee Graduate School of Medicine, Knoxville, TN (11/2005 – present)
Awards and Honors
2011 World Molecular Imaging Congress
San Diego, California
Inveon Image of the Year Award 2011
Translational Image of the Year Award 2011
GSM Faculty Award 2011
GSM Spirit Award
University of Tennessee Graduate School of Medicine, June 2011
Visiting Professor
Amyloid, melanoma and the missing molecular link
University of Uppsala,
Uppsala, Sweden, April 7th 2011
Visiting Professor
Animal imaging in basic, clinical, and translational research
Biochemistry and Molecular Biology Seminar Series,
The
Mayo Clinic,
Rochester, MN. March 1st 2011
2010
World Molecular Imaging Congress
Kyoto, Japan
Inveon Image of the Year 2010
Best Presented Image of the Year 2010
Siemens Preclinical Image of the Year
Siemens Workshop at the AMI/SMI Joint Molecular Imaging Conference, Providence, RI, September, 2007
GSM Faculty Award
Excellence in Leadership and Performance of Basic Science Award, University of Tennessee Graduate School of Medicine, June 2006.
Society Memberships
Member of the American Association of Immunologists (2001-present)
Society of Nuclear Medicine (May 2007-present)
American Association for Laboratory Animal Science (Gold Membership; 2007- present)
International Society of Amyloidosis (Jan 2008- present)
Honorary member Phi Zeta – the Honor Society of Veterinary Medicine (April 2008-present)
Publications
Books and Book Chapters
Wall, J.S. and Bartges, J. (2010), Renal Amyloidosis in Small animals. In Nephrology and Urology of Small Animals, J. Bartges and D. Polzin (eds). In press.
Wall, J.S. (2010), Immunotherapy in Secondary Reactive Amyloidosis and Light Chain Amyloidosis. In Protein Misfolding Diseases: Current and Emerging Principles and Therapies, M. Ramirez-Alvarado, C. Dobson and J. Kelly (eds.), Chapter 42, p. 917, Wiley & Sons, Hoboken, NJ.
Wall, J.S. and Bartges, J. (2008), Renal Amyloidosis in Small animals. In Nephrology and Urology of Small Animals, J. Bartges and D. Polzin (eds). Manuscript in Preparation
Wall, J.S. (2008), Immunotherapy in Secondary Reactive Amyloidosis and Light Chain Amyloidosis. In Protein Misfolding Diseases: Current and Emerging Principles and Therapies , M. Ramirez-Alvarado, C. Dobson and J. Kelly (eds.), Wiley & Sons, Hoboken, NJ. Manuscript accepted
Tobin, K.W., Chaum, E., Gregor, J., Karnowski, T.P., Price, J.R. and Wall, J.S. (2008) Image informatics for clinical and preclinical biomedical analysis. In, Computational Intelligence in Medical Imaging: Techniques & Applications, CRC Press, Boca Raton, FL. In press
Gregor, J., Gleason, S.S., Kennel, S.K., Paulus, M.J., Solomon, A., Hawkins, P.N., and Wall, J.S. (2005), A microSPECT/CT system for imaging of AA-amyloidosis in mice. In Small-Animal SPECT Imaging, Chapter 14, M. Kupinski and H. Barrett (eds.), Plenum, USA
Wall, J.S., Schell., M., Hrncic, R., Stevens, F.J. and Solomon, A. (2003) Fibrillogenesis and therapy of amyloidosis: an equilibrium approach. In, Monoclonal Gammopathies and the Kidney, G. Touchard, P. Aucouturier, O. Hermina and P. Ronco (eds.), p. 203-214, Kluwer Academic, Dordrecht, Netherlands.
Current Peer-Reviewed Journal Articles Present-2008
Wall, J.S., Richey, T., Stuckey, A., Donnell, R., Oosterhof, A., van Kuppevelt, T.H., Smits, N.C., and Kennel, S.J. (2011) Imaging peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies, Nuclear Medicine and Biology, In press
Wall, J.S., Richey, T., Williams, A., Stuckey, A., Martin, E., and Kennel, S.J.K. (2011) Comparative analysis of peptide p5 and serum amyloid P component for imaging AA amyloid in mice using dual-isotope SPECT, Molecular Imaging and Biology, In press
Wall, J.S., Solomon, A., and Kennel, S.J. (2011) Development and evaluation of agents for targeting visceral amyloid, Tijdschrift voor Nucleaire Geneeskunde, In press
LeBlanc, A., Miller, A.N., Galyon, G.D., Moyers, T.D., Long, M.J., Stuckey, A.C., Wall, J.S., and Morandi, F. (2011) Utility of Serial 18FDG-PET/CT to Assess Response to Receptor Tyrosine Kinase Inhibition in Canine Cancer, Veterinary Radiology and Ultrasound. Submitted
Wall JS, Richey T, Stuckey A, Donnell R, Macy S, Martin EB, Williams A, Higuchi K, Kennel SJ.
In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E586-94. Epub 2011 Aug 1.
PMID:21807994
Stuart CA, Ross IR, Howell ME, McCurry MP, Wood TG, Ceci JD, Kennel SJ, Wall J.
Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake.
Brain Res. 2011 Apr 12;1384:15-22.
PMID:21316350
Kestler DP, Foster JS, Bruker CT, Prenshaw JW, Kennel SJ, Wall JS, Weiss DT, Solomon A.
ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.
Breast Cancer (Auckl). 2011;5:73-85. Epub 2011 Apr 28.
PMID:21603257
Jonathan S. Wall, Stephen J. Kennel, Tina Richey, Amy Allen, Alan Stuckey, Deborah T. Weiss, Sallie Macy, Robin Barbour, Peter Seubert, Alan Solomon, and Dale Schenk (2011) Generation and characterization of anti-AA amyloid-specific monoclonal antibodies, Frontiers in Immunology, 2:32.
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Souza MJ, Wall JS, Stuckey A, Daniel GB.
Static and dynamic (18) FDG-PET in normal hispaniolan Amazon parrots (Amazona ventralis).
Vet Radiol Ultrasound. 2011 May-Jun;52(3):340-4.
PMID: 21554485
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Lyons JA, Dickson PI, Wall JS, Passage MB, Ellinwood NM, Kakkis ED, McEntee MF.
Arterial pathology in canine mucopolysaccharidosis-I and response to therapy.
Lab Invest. 2011 May;91(5):665-74.
PMID: 21383673
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Woodward J, Kennel SJ, Stuckey A, Osborne D, Wall J, Rondinone AJ, Standaert RF, Mirzadeh S.
LaPO4 nanoparticles doped with actinium-225 that partially sequester daughter radionuclides.
Bioconjug Chem. 2011 Apr 20;22(4):766-76.
Kennel SJ, Huang Y, Zeng WB, Stuckey A, Wall J.
Kinetics of Vascular Targeted Monoclonal Antibody.
Curr Drug Deliv. 2010 Dec;7(5):428-35.
PMID: 20950267
Smits NC, Kurup S, Rops AL, Ten Dam GB, Massuger LF, Hafmans T, Turnbull JE, Spillmann D, Li JP, Kennel SJ, Wall JS, Shworak NW, Dekhuijzen PN, van der Vlag J, van Kuppevelt TH.
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.
J Biol Chem. 2010 Dec 24;285(52):41143-51.
PMID: 20837479
Xing L, Li TC, Miyazaki N, Simon MN, Wall JS, Moore M, Wang CY, Takeda N, Wakita T, Miyamura T, Cheng RH.
Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway.
J Biol Chem. 2011 Jan 28;286(4):2956-65.
PMID: 20720013
Davern S, Murphy CL, O'Neill H, Wall JS, Weiss DT, Solomon A.
Effect of lysine modification on the stability and cellular binding of human amyloidogenic light chains.
Biochim Biophys Acta. 2011 Jan;1812(1):32-40.
PMID: 20692337
Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S.
Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
Biochem Biophys Res Commun. 2010 Sep 10;400(1):60-5.
PMID: 20691664
Phipps JE, Kestler DP, Foster JS, Kennel SJ, Donnell R, Weiss DT, Solomon A, Wall JS.
Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules.
Exp Hematol. 2010 Nov;38(11):1006-13.
PMID: 20637260
Wall JS, Kennel SJ, Stuckey AC, Long MJ, Townsend DW, Smith GT, Wells KJ, Fu Y, Stabin MG, Weiss DT, Solomon A. Radioimmunodetection of amyloid deposits in patients with AL amyloidosis.
Blood. 2010 Sep 30;116(13):2241-4.
PMID: 20522711
LeBlanc AK, Wall JS, Morandi F, Kennel SJ, Stuckey A, Jakoby B, Townsend DW, Daniel GB.
Normal thoracic and abdominal distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) in adult cats.
Vet Radiol Ultrasound. 2009 Jul-Aug;50(4):436-41.
PMID: 19697611
Wall JS, Richey T, Allen A, Donnell R, Kennel SJ, Solomon A. Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice.
Comp Med. 2008 Dec;58(6):542-50.
PMID: 19149411
O'Nuallain B, Acero L, Williams AD, Koeppen HP, Weber A, Schwarz HP, Wall JS, Weiss DT, Solomon A.
Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies.
Biochemistry. 2008 Nov 25;47(47):12254-6.
PMID: 18956886
Davern S, Tang LX, Williams TK, Macy SD, Wall JS, Weiss DT, Solomon A.
Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies.
Am J Clin Pathol. 2008 Nov;130(5):702-11.
PMID: 18854262
Souza MJ, Newman SJ, Greenacre CB, Avenell JS, Wall JS, Phillips JC, Fry MM, Donnell RL, Daniel GB.
Diffuse intestinal T-cell lymphosarcoma in a yellow-naped Amazon parrot (Amazona ochrocephala auropalliata).
J Vet Diagn Invest. 2008 Sep;20(5):656-60.
PMID: 18776105
del Pozo Yauner L, Ortiz E, Sánchez R, Sánchez-López R, Güereca L, Murphy CL, Allen A, Wall JS, Fernández-Velasco DA, Solomon A, Becerril B.
Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains.
Proteins. 2008 Aug;72(2):684-92.
PMID: 18260098
Davern S, Tang LX, Williams TK, Macy SD, Wall JS, Weiss DT, Solomon A.
Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies.
Am J Clin Pathol. 2008 Nov;130(5):702-11.
PMID: 18854262
O'Nuallain B, Allen A, Ataman D, Weiss DT, Solomon A, Wall JS.
Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope.
Biochemistry. 2007 Nov 13;46(45):13049-58.
PMID: 17944486
Solomon A, Richey T, Murphy CL, Weiss DT, Wall JS, Westermark GT, Westermark P.
Amyloidogenic potential of foie gras.
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10998-1001.
PMID: 17578924
Smith JR, Legendre AM, Thomas WB, LeBlanc CJ, Lamkin C, Avenell JS, Wall JS, Hecht S.
Cerebral Blastomyces dermatitidis infection in a cat.
J Am Vet Med Assoc. 2007 Oct 15;231(8):1210-4.
PMID: 17937550
Woodward, J., Kennel, S., Mirzadeh, S., Dai, S., Wall, J.S., Richey, T., Avenell, J. and Rondinone, A.J. (2007) In vivo SPECT/CT imaging and biodistribution using radioactive Cd125mTe/ZnS nanoparticles.
Nanotechnology, 18, 175103
O'Nuallain B, Allen A, Ataman D, Weiss DT, Solomon A, Wall JS.
Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope.
Biochemistry. 2007 Nov 13;46(45):13049-58.
PMID: 17944486
Kennel SJ, Woodward JD, Rondinone AJ, Wall J, Huang Y, Mirzadeh S.
The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo.
Nucl Med Biol. 2008 May;35(4):501-14. Epub 2008 Apr 3.PMID: 18482688
Zeng W, Yao ML, Townsend D, Kabalka G, Wall J, Le Puil M, Biggerstaff J, Miao W.
Synthesis, biological evaluation and radiochemical labeling of a dansylhydrazone derivative as a potential imaging agent for apoptosis.
Bioorg Med Chem Lett. 2008 Jun 15;18(12):3573-7.
PMID: 18490161
Davern S, Tang LX, Williams TK, Macy SD, Wall JS, Weiss DT, Solomon A.
Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies.
Am J Clin Pathol. 2008 Nov;130(5):702-11.
PMID: 18854262
Shashikant Kulkarni, S., Nagarajan, P., Wall, J.S., Donovan, D., Donell, R.L. Ligon, A.H., Venkatachalam, S., Quade, B.J. (2008) Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis. American Journal Medical Genetics, Part A, 146A, (9), 117-1127
The University of Tennessee Graduate School of Medicine
Preclinical and Diagnostic Molecular Imaging
Laboratory
1924 Alcoa Highway
Knoxville, TN
37920-6999
Phone: 865 305 8497