Jonathan S. Wall, PhD

Director, Preclinical and Diagnostic Molecular Imaging
Laboratory
Professor, Department of Medicine
Human Immunology and Cancer Program

Education

Postdoctoral
University of Tennessee Medical Center
Human Immunology & Cancer Program
Knoxville, TN (January 1995- April 1997)

Graduate
University of Essex
Department of Chemistry & Biological Chemistry, Colchester, UK (October 1991- December 1994).
Ph.D conferred July 1995

Undergraduate
University of Essex
Department of Biology
Colchester, UK (October 1987-June 1991).
BSc. (Hons.) Biological Sciences, July 1991

Faculty Appointments

Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2009 - present)

Associate Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (June 2003 – June 2009)

Assistant Professor, University of Tennessee Graduate School of Medicine, Knoxville, TN (April 1997- June 2003)

Adjunct Associate Professor, Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, TN (July 2007 – present)

Director, Preclinical and Diagnostic Molecular Imaging Laboratory, University of Tennessee Graduate School of Medicine, Knoxville, TN (11/2005 – present)

Honors

Faculty Award
Excellence in Leadership and Performance of Basic Science Award, University of Tennessee Graduate School of Medicine, June 2006.

Siemens Preclinical Image of the Year
Siemens Workshop at the AMI/SMI Joint Molecular Imaging Conference, Providence, RI, September, 2007

Society Memberships

Member of the American Association of Immunologists (2001-present)

Society of Nuclear Medicine (May 2007-present)

American Association for Laboratory Animal Science (Gold Membership; 2007- present)

International Society of Amyloidosis (Jan 2008- present)

Honorary member Phi Zeta – the Honor Society of Veterinary Medicine (April 2008-present)

Publications

Books and Book Chapters
Wall, J.S., Schell., M., Hrncic, R., Stevens, F.J. and Solomon, A. (2003) Fibrillogenesis and therapy of amyloidosis: an equilibrium approach. In, Monoclonal Gammopathies and the Kidney, G. Touchard, P. Aucouturier, O. Hermina and P. Ronco (eds.), p. 203-214, Kluwer Academic, Dordrecht, Netherlands.

Gregor, J., Gleason, S.S., Kennel, S.K., Paulus, M.J., Solomon, A., Hawkins, P.N., and Wall, J.S. (2005), A microSPECT/CT system for imaging of AA-amyloidosis in mice. In Small-Animal SPECT Imaging, Chapter 14, M. Kupinski and H. Barrett (eds.), Plenum, USA

Tobin, K.W., Chaum, E., Gregor, J., Karnowski, T.P., Price, J.R. and Wall, J.S. (2008) Image informatics for clinical and preclinical biomedical analysis. In, Computational Intelligence in Medical Imaging: Techniques & Applications, CRC Press, Boca Raton, FL. In press

Wall, J.S. (2008), Immunotherapy in Secondary Reactive Amyloidosis and Light Chain Amyloidosis. In Protein Misfolding Diseases: Current and Emerging Principles and Therapies , M. Ramirez-Alvarado, C. Dobson and J. Kelly (eds.), Wiley & Sons, Hoboken, NJ. Manuscript accepted

Wall, J.S. and Bartges, J. (2008), Renal Amyloidosis in Small animals. In Nephrology and Urology of Small Animals, J. Bartges and D. Polzin (eds). Manuscript in Preparation

Current Peer-Reviewed Journal Articles 2007-present

O’Nuallain, B., Allen, A., Ataman, D., Weiss, D.T., Solomon, A. and Wall, J.S. (2007). The fibril reactive antibody 11-1F4 binds a conformational epitope on amyloid and denatured light chain proteins, Biochemistry,46, (5), 1240-1247

Woodward, J., Kennel, S., Mirzadeh, S., Dai, S., Wall, J.S., Richey, T., Avenell, J. and Rondinone, A.J. (2007) In vivo SPECT/CT imaging and biodistribution using radioactive Cd125mTe/ZnS nanoparticles. Nanotechnology, 18, 175103

Solomon, A., Richey, T., Murphy, C.L., Weiss, D.T., Wall, J.S., Westermark, G.T. and Westermark, P. (2007) Amyloidogenic potential of foie gras. Proc. Natl. Acad. Sci., 105, (26), 10998-11001

Smith, J.R., LeBlanc, C., Legendre, A., Thomas, W.B., Avenell, J., Wall, J.S. and Hecht, S. (2007) Cerebral Blastomycosis dermatitidis in a cat. J. Am. Vet Med. Assoc. 231, (8) 1210-1214

O’Nuallain, B., Allen, A., Ataman, D., Weiss, D.T., Solomon, A. and Wall, J.S. (2007). Peptide Mimetics of a Conformational Fibril Epitope Identified by Phage Display. Biochemistry, 46 ( 45): 13049-58. Epub 2007 Oct 18

Kennel, S.J., Wall, J.S., Woodward, J.D., Rondinone, A.J., Huang, Y. and Mirzadeh, S. (2008) The Fate of MAb targeted Cd(125m)Te/ZnS nanoparticles in vivo. Nuclear Medicine and Biology, 35, (4), 501-514

Zeng, W., Yao, M., Townsend, D., Kabalka, G., Wall, J.S., Le Puil, M., Biggerstaff, J. and Miao, W. (2008) Synthesis and biological evaluation of a radiolabeled dansylhydrazone derivative as an imaging agent for apoptosis. Bioorganic and Medicinal Chemistry Letters, 18, (12), 3573-3577

del Pozo Yauner, L., Sánchez, R., Sánchez, R., Güereca1, L., Ortiz, E., Allen, A., Murphy, C., Wall, J.S., Fernández, A., Solomon, A., and Becerril1, B. (2008). The influence of the germline sequence on the in vitro fibrillogenicity and thermodynamic stability of lambda VI light chains. Proteins, 72, (2), 684-692

Shashikant Kulkarni, S., Nagarajan, P., Wall, J.S., Donovan, D., Donell, R.L. Ligon, A.H., Venkatachalam, S., Quade, B.J. (2008) Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis. American Journal Medical Genetics, Part A, 146A, (9), 117-1127

Souza, M.J., Newman, S.J., Greenacre, C.B., Wall, J.S., Avenell, J.S., Phillips, J.C., Fry, M.M., Donnell, R.L. and Daniel, G.B. (2008) Diffuse intestinal T-cell lymphosarcoma in a yellow-naped Amazon parrot (Amazona ochrocephala auropalliata). J. Veterinary Diagnostic Investigation, 20, 656-660

Davern, S, Tiang, L.X., Williams, T.K., Macy, S.D., Wall, J.S., Weiss, D.T. and Solomon, A. (2008) Immunodiagnostic Capabilities of Anti-Free Immunoglobulin Light Chain Monoclonal Antibodies. , Am. J. Clin. Path., 2008 Nov;130(5):702-11.

Wall, J.S. , Richey, T. Allen, A., Donnell, R., Kennel, S.J., and Solomon, A. (2008) Quantitative microSPECT/CT imaging of early onset spontaneous AA amyloidosis in H2/huIL-6 transgenic mice. J. Comparative Medicine, 2008 Dec;58(6):542-50.

 

 

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