Stephen J. Kennel, Ph.D.
Radio-Biochemist, Preclinical and Diagnostic Molecular Imaging Laboratory
Associate Professor
Department of Medicine
Education
University of California, San Diego, CA - 1971
Ph.D. Chemistry
University of California, San Diego, CA - 1968
M.S. Chemistry
University of Illinois - 1967
B.S. Chemistry
Positions and Honors
2005-present
Associate Professor, University of Tennessee Graduate School of Medicine
1998-2005
Distinguished Senior Staff Scientist, Oak Ridge National Laboratory
1981-1998
Senior Staff Scientist, Oak Ridge National Laboratory
1974-1976
Associate, Department of Immunopathology, Scripps Clinic and Research Foundation
1973-1974
Assistant, Department of Experimental Pathology, Scripps Clinic and Research Foundation
1971-1973
Research Fellow, Department of Experimental Pathology, Scripps Clinic and Research Foundation
1967-1971
USPHS Graduate Trainee Fellow, University of California
1966
Research Assistant, Northern Regional Laboratory
Selected peer-reviewed publications (Selected from >150)
Kennel SJ, Huang Y, Zeng WB, Stuckey A, Wall J.
Kinetics of Vascular Targeted Monoclonal Antibody.
Curr Drug Deliv. 2010 Oct 15.
PMID: 20950267
Kennel, S.J., M. Stabin, J.C.Roeske, L.J. Foote, P.K. Lankford, P. Terzaghi-Howe, H. Patterson, J. Barkenbus, D.M. Popp, R. Boll, and S. Mirzadeh. Radiotoxicity of 213Bi Bound to Membranes of Monolayer and Spheroid Cultures of Tumor Cells. Rad. Res., 151, 244-256,1999.
Kennel, S.J., M. Stabin, M. Brechbiel, and S. Mirzadeh. Treatment of lung tumor colonies with 90Y targeted to blood vessels-Comparison with the α-emitter 213Bi. Nucl. Med. Biol., 26,149-157,1999.
Kennel S.J., P.K. Lankford, L.J. Foote, and I.A. Davis. Monoclonal Antibody to Rat CD63 Detects Different Molecular forms in Rat Tissues. Hybridoma, 17,509-515, 1998.
Davis, I.A. and S.J. Kennel Radioimmunotherapy using vascular targeted 213Bi: The role of TNF-α in the development of pulmonary fibrosis. Clinical Cancer Research, 5, 3160s-3194s, 1999.
Cagle,D.W., S.J. Kennel, S. Mirzadeh, J.M. Alford, and L.J. Wilson,. In Vivo Studies of Fullerene-Based Materials Employing Endohedral Metallofullerene Radiotracers. PNAS, 96, 5182-5187, 1999.
Hurst, G. B., M.V. Buchanan, L.J. Foote, and S. J. Kennel. Analysis for TNF-α using solid-phase capture with radiolabel and MALDI-MS detection Anal. Chem., 71, 4727-4733, 1999.
Kennel, S. J., T. K. Lankford, L. J. Foote, I. A. Davis, R. A. Boll and S. Mirzadeh. Combination Vascular Targeted and Tumor Targeted Radioimmunotherapy. Cancer Biotherapy and Radiopharmaceuticals, 14, 371-379, 1999.
Paulus, M. J., et. al High Resolution X-ray Computed Tomography: An Emerging Tool for Small Animal Cancer Research. Neoplasia 2, 62-70, 2000.
Kennel, S. J., S. Mirzadeh,, G. Hurst, L. J. Foote, T. K. Lankford, K. A. Glowienka, L. L. Chappell, J. Kelso, S. M. Davern, A. Safavey, and M. W. Brechbiel. Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors. Nucl. Med Biol. 27, 815-825, 2000.
Kennel, S. J., I. A. Davis, J. Branning, H-J. Pan, G. W. Kabalka, and M. J. Paulus. High Resolution Computed Tomography and MRI for Monitoring Lung Tumor Growth in Mice Undergoing Radioimmunotherapy: Correlation with Histology. J Med Phys. 27, 1101-1107, 2000.
Kennel, S. J., M. W. Brechbiel, M. Deal, E. Dadachova, T. K. Lankford, I. A. Davis, M. Stabin and S. Mirzadeh. Evaluation of 225Ac for Vascular Targeted Radioimmunotherapy of Lung Tumors. Cancer Biotherapy and Radiopharmaceuticals 15, 235-244, 2000.
Kennel, S. J., S. Mirzadeh, W. C. Eckleman, T. A. Waldmann, K. Gharmestani, A Yordanov, M. Stabin and M. W. Brechbiel. Vascular Targeted Radioimmunotherapy with the α-Emitter 211At. Rad Research 157, 633-641, 2002.
Kennel, S. J., M. W. Brechbiel, D Milnec, J. Schlom and S. Mirzadeh. Actinium-225 conjugates of MAb CC49 and ∆CH2CC49: Therapy of LS174T tumors in nude mice. Cancer Biotherapy and Radiopharaceuticals 17,219-231, 2002.
Kennel, S. J., T. Lankford, S. Davern, L. Foote, K. Taniguchi, I. Ohizumi, Y. Tsutsumi, S. Nakagawa T. Mayumi and S. Mirzadeh. Therapy of rat tracheal carcinoma IC-12 in SCID mice: Vascular targeting with 213Bi-MAb TES-23. European J.Cancer, 38, 1278-1287, 2002.
Subramanian A., P. I. Olden, S. J. Kennel, K. B. Jacobson, R. J. Warmack, T. Thundat and M. J. Doktycz. Glucose biosensing using an enzyme-coated microcantilever. Applied Physics Letters 81, 385-387, 2002.
Davern S. M., P. K. Lankford, L. J. Foote and S. J. Kennel. Monoclonal antibodies to CD-44 epitopes on mouse endothelium. Hybridoma and Hybridomics 21 , 339-349, 2002.
Akabani G., Kennel S. J. and M. R. Zalutsky. Microdosimetric analysis of alpha particle emitting targeted radiotherapeutics using histological images. J. Nucl. Med. 44. 792-805, 2003.
Jamasbi, R. J., Stoner, G. D., Foote, L.J., Lankford, T. K. Davern, S. and S. J. Kennel. A monoclonal antibody to a carbohydrate epitope expressed on glycolipid and on α3β1 integrin on human esophageal carcinoma. Hybridoma and Hybridomics 22, 367-376, 2004.
DeNardo G. L., Kennel S. J., Siegel J. A. and S. J. DeNardo Radiometals as Payloads for Radioimmunotherapy for Lymphoma. Clin Lymphoma 5, S5-S10, 2004.
Kennel, S. J., Lankford, T., Foote, L., Wall, M. and S. Davern. Phage display selection of scFv to murine endothelial cell membranes. Hybridoma and Hybridomics 23. 205-211, 2004.
Buchanan M. V., Larimer F. W., Wiley H. S., Kennel S. J., Squier T. J., Ramsey J. M., Rodland K. D., Hurst G. B., Smith R. D., Xu Y., Dixon D., Doktycz M. J., Colson S., Gesteland R., Giometti C., Young M., and M. Giddings. Genomes to life “center for Molecular and cellular systems”: A research program for the identification and characterization of protein complexes. OMICS 6, 287-303, 2002.
Davern S. M., Foote L. J., Lankford P. K., Macy S. D., Wall M. D. and S. J. Kennel. Identification of an anti-laminin-1 scFv that preferentially homes to vascular solid tumors. Cancer Biotherapy and Radiophamaceuticals, 20, 524-533, 2005.
Wall J. S., Kennel S. J., Paulus M. J., Gleason S.,Gregor J., Baba J., Schell M., Ramsey T., O’Nullian B., Donnell R., Hawkins P. N., Weiss D., and A. Solomon. Quantitative High-resolution microautoradiographic imaging of amyloid deposit in a novel murine model of AA-amyloidosis. Amyloid: The Journal of Protein Folding Disorders, 12, 149-156 (2005).
Huang B. C., Foote L. J., Lankford P. K., Davern S. M., McKewon, C. and S. J. Kennel. A diabody that dissociates to monomer forms at low concentration: Effects on binding activity and tumor targeting. Biochem and Biophys Res Comm 327, 999-1005 (2005).
Kennel S.J.,Lankford, T, Garland M, Sunderberg, J.P. and Mirzadeh, S. Boidistribution of 225Ra citrate in mice: retention of daughter radioisotopes in bone Nuc Med Biol 32, 859-867 (2005).
Wilson A, Zhou W, Champion HC, Alber S, Tang ZL, Kennel S, Watkins S, Huang L, Pitt B, Li S.
Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo.
Mol Ther. 2005 Sep;12(3):510-8.
Gregor J., Gleason S., Kennel S., Paulus M., Benson T., and Wall J. Approximate Volumetric System Models for MicroSPECT. IEE Transactions Nuclear Science 2006 Oct; 53(5):2646-52.
Van Berkel G. J., Ford M. J., Doktycz M. J., and S. J. Kennel. Evaluation of a surface-sampling probe electrospray mass spectrometry system for the analysis of surface-deposited and affinity-captured proteins. Rapid Comm in Mass Spectrometry 20(7), 1144-52, 2006.
Huang B-C, Davern S and S. J. Kennel. Mono and bivalent binding of a scFv and covalent diabody to murine laminin-1 using radioiodinated proteins and SPR measurements: Effects on tissue retention in vivo. J Immunol. Methods 313, 149-160 (2006).
Wall J.S., Paulus M.J., Gleason S., Gregor J., Solomon A., and Kennel S. J. Micro-Imaging of amyloid in mice. Methods in Enzylogy 412 [11] 161-182 (2006).
Wall J. S., Kennel S.J., Paulus M., Gregor J., Richey T., Avenell J., Yap J., Townsend D., Weiss D., and Solomon A. Radioimaging of AL amyloid using a fibril-reative monoclonal antibody. J. Nucl. Med 2006 Dec;47(12):2016-2024.
Lee, T.H., Seng, S.,Kennel, S. J.,Karsenty Avraham, H., and Avraham, S. Integrin regulationby VEGF in human brain microvascular endothelial cells: role of alpha 6 beta 1 integrin in angiogenesis. J. Biol Chem 2006 Dec 29;281(52):40450-60
O'Nuallain B., Allen A., Kennel S. J., Weiss D., Solomon, A. and Wall, J. S. Localization of a Conformational Epitope Common to Non-Native and Fibrillar Immunoglobulin Light Chains. Biochemistry 2007 Feb 6;46(5):1240-7.
Shuvaev VV, Christofidou-Solomidou M, Scherpereel A, Simone E, Arguiri E, Tliba S, Pick J, Kennel S, Albelda SM, Muzykantov VR. Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium. J Control Release 2007 Apr 2;118(2):235-44.
Diener MD, Alford JM, Kennel SJ, Mirzadeh S (212)Pb@C(60) and its water-soluble derivatives: synthesis, stability, and suitability for radioimmunotherapy. J Am Chem Soc 2007 Apr 25;129(16):5131-8.
Kennel SJ, Woodward JD, Rondinone AJ, Wall J, Huang Y, Mirzadeh S. The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo. Nucl Med Biol 2008 May;35(4):501-14.
Murphy CL, Kestler DP, Foster JS, Wang S, Macy SD, Kennel SJ, Carlson ER, Hudson J, Weiss DT, Solomon A. Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles. Amyloid. 2008 Jun;15(2):89-95.
The University of Tennessee Graduate School of Medicine
Preclinical and Diagnostic Molecular Imaging Laboratory
1924 Alcoa Highway
Knoxville, TN
37920-6999
Phone: 865 305 8497