Research
Research Laboratories
Anesthesiology Research Facility
The Anesthesiology Research Laboratory supports the faculty and residents of the Department of Anesthesiology by performing clinical research on pain and nausea management, regulation and monitoring of blood clotting, aspirin resistance in cardiovascular disease, as well as, the effects of anesthesia.
Cancer Cell Biology Laboratory
The Cancer Cell Biology Laboratory focuses on how growth and death of breast and ovarian cancer cells is regulated by estrogens and chemotherapy agents like paclitaxel. Future studies may lead to the identification of cellular targets in cancer cells which may prevent growth and/or induce death in cancer cells.
Conformational Diseases & Therapeutics Research
The Conformational Diseases and Therapeutics Research Lab works on understanding the mechanism(s) of protein folding and misfolding, and to decipher how these processes are related to normal physiology and disease using chemical, biophysical and cell biology approaches. The lab is currently focusing on two amyloid like diseases, Huntington’s disease and Occulopharyngeal Muscular Dystrophy. Studies include the aggregation phenomena and using high-throughput screening assays to identify small molecules as potential leads to therapeutics.
Human Immunology & Cancer Program
The Human Immunology and Cancer Program is a multifaceted basic and clinical scientific endeavor devoted to advancing understanding of the pathogenesis of primary amyloidosis and developing innovative diagnostic and therapeutic means; the ultimate goal is to eventually diminish or eradicate the calamitous effects of this disease.
Molecular Imaging & Translational Research Program
Research objectives in PET instrumentation include advances in PET/CT methodology and the assessment of the role of combined PET/CT imaging for a range of different cancers. This work with human subjects will be complemented by parallel studies involving specific animal models of cancer, and eventually the development of new molecular probes that target different aspects of tumor physiology and the effects of therapy in patients
Preclinical & Diagnostic Molecular Imaging Laboratory
The Preclinical and Diagnostic Molecular Imaging Laboratory's aim is to facilitate the translation of novel therapies and diagnostic agents into patients by providing proof-of-principle data in animal models of disease, as required by the US Food and Drug Administration. The laboratory focuses on research into amyloid-associated disorders, cancer, atherosclerosis and diagnostic veterinary imaging.
The Shock Trauma & Nutrition Research Laboratories
Current research interests include vascular biology and cardiovascular physiology, platelet physiology, nutrition, bioterrorism, non-linear dynamic modeling, trauma, and transplantation immunology. In addition to research projects within the various divisions of the Department of Surgery, collaborative investigators in the Departments of Medical Genetics, Anesthesiology, Pathology, Medicine, Radiology and the UT College of Veterinary Medicine offer an extensive assortment of projects including immunology, hematology, cell physiology, medical genetics, tumor biology, molecular biology and cytometry.
The Vascular Research Laboratory’s mission is to take a collaborative approach to translational research of peripheral vascular pathology with scientists and physicians working closely together on clinically significant research endeavors. The primary focus is to conduct research into the biology of cells making up the peripheral blood vessels via methods in cellular and molecular biology. The Vascular Research Laboratory also supports clinical research projects within the Department of Surgery and plays a primary role in research education for surgical residents, vascular fellows, and undergraduate and graduate students.
The University of Tennessee Graduate School of Medicine
Office of the Dean
1924 Alcoa Highway, U94
Knoxville, TN 37920
Phone: (865) -305-9290 or
(800)-596-7249
Fax: (865) 305-6819