Faculty
Roger C. Carroll, Ph.D.
Professor and Director of Anesthesiology Research
Graduate School
Cornell University, Ithaca, NY; Ph.D. (1977) in 1971 - 1976
the Department of Biochemistry
Postgraduate
Postdoctoral Fellow, University of California at 1976 - 1978
San Diego, CA in the Department of Biology
Postdoctoral Fellow, University of Oklahoma 1978 - 1979
Health Sciences Center, Oklahoma City, OK
in the Department of Pathology
Honors
New York State Regents Scholarship 1965 - 1969
New York State Scholarship Incentive Award 1973 - 1976
Dupont Teaching Award, Cornell University 1974
Oklahoma Medical Research Foundation Merrick
Award for Outstanding Young Scientists 1984
Who's Who in America 1994 - present
Who's Who in the World 1994 - present
Who's Who in Medicine and Healthcare 2000 - present
Recent Publications
(Invited Reviews)
Hosking, M.P., Carroll, R.C. : Roxifiban. Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs 2: 165-171, 2000.
Liu, F., Bagley, W.P., Carroll, R.C. : SR-90107 (Synthetic Pentasaccharide):A Factor Xa Antagonist. Investigational Drugs 3: 1088-1099, 2000.
Liu, F., Craft, R.M., Morris, S.A., Carroll, R.C. : Lotrafiban - SmithKline Beecham: An Oral Platelet Glycoprotein IIb/IIIa Blocker and Related Issues. Expert Opinion on Investigational Drugs 9 (11): 2673-2687, 2000.
(Seminal & Recent Peer-Reviewed Journal Articles):
Carroll, R.C. , Butler, R.G., Morris, P.A. and Gerrard, J.M.: Separable assembly of platelet pseudopodal and contractile cytoskeletons. Cell 30: 385-393, 1982.
Esmon, M.L., Carroll, R.C. and Esmon, C.T.: Thrombomodulin blocks the ability of thrombin to activate platelets. Journal of Biological Chemistry 258: 12238-12242, 1983.
Cox, A.C., Carroll, R.C., White, J.G. and Rao, G.H.R.: Recycling of platelet phosphorylation and cytoskeletal assembly. Journal of Cell Biology 98: 8-15, 1984.
Wheeler, M.E., Cox, A.C. and Carroll, R.C. : Retention of the glycoprotein IIb-IIIa complex in the isolated platelet cytoskeleton: Effect of separable assembly of platelet pseudopodal and contractile cytoskeletons. Journal of Clinical Investigation 74: 1080-1089, 1984.
Wheeler, M.E., Gerrard, J.M. and Carroll, R.C. : Reciprocal transmembraneous receptor-cytoskeletal interactions in concanavalin A-activated platelets. Journal of Cell Biology 101: 993-1000, 1985.
Low, M.G., Carroll, R.C. , and Cox, A.C.: Characterization of multiple forms of phosphoinositide-specific phospholipase C purified from human platelets. Biochemistry Journal 237: 139-145, 1986.
Rubinstein, E., Urso, I., Boucheix, C., and Carroll, R.C. Platelet activation by cross-linking HLA class I molecules and Fc receptor. Blood 79: 2901-2908, 1992.
Carroll, R.C. , Wang, X-F., Lanza, F., Steiner, B., and Kouns, W.C.: Blocking platelet aggregation inhibits thromboxane A2 formation by low dose agonists but does not inhibit phosphorylation and activation of cytosolic phospholipase A2 . Thrombosis Research 88: 109-125, 1997.
Rowe, V.L., Stevens, S.L., Reddick, T.T., Freeman, M.B., Donnell, R., Carroll, R.C. , and Goldman, M.H.: Vascular smooth muscle apoptosis in aneurysmal, occlusive, and normal human aortas. Journal of Vascular Surgery 31: 567-576, 2000.
Karlstad, M.D., Buripakdi, D., Carroll, R.C. : Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. Shock 14: 490-498, 2000.
Liu F, Bagley WP, Carroll RC. SR-90107 (Sanofi-Synthélabo). IDrugs. 2000 Sep;3(9):1088-99.
Liu F, Craft RM, Morris SA, Carroll RC. Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker. Expert Opin Investig Drugs. 2000 Nov;9(11):2673-87.
Grandas, O.H., Costanza, M.J., Donnell, R.L., Reddick, T.T., Carroll, R.C., Stevens, S.L., Freeman, M.B., Goldman, M.H.: Effect of retroviral transduction of canine microvascular endothelial cells on beta(1) integrin subunit expression and cell retention to PTFE grafts. Cardiovascular Surgery 9(6): 595-599, 2001.
Wang, X.-F., Liu, F., Morris, S.A., Carroll, R.C. : Synergistic outside-in regulation of platelet activation by GPIIb/IIIa ligand-induced conformation and oligomerization. Thrombosis Research 104: 239-247, 2001.
Liu, F., Morris, S.A., Epps, J.L., Carroll, R.C. : Demonstration of an Activation Regulated NF-kB/I-kBa Complex in Human Platelets Thrombosis Research 106: 199-203, 2002
Bagley WP, Smith AA, Hebert JD, Snider CC, Sega GA, Piller MD, Carney PC, Carroll RC. A randomized, placebo controlled, trial of preoperative sustained release Betamethasone plus non-controlled intraoperative Ketorolac or Fentanyl on pain after diagnostic laparoscopy or laparoscopic tubal ligation [ISRCTN52633712]. BMC Anesthesiol. 2003 Aug 21;3(1):3.
Craft RM, Chavez JJ, Bresee SJ, Wortham DC, Cohen E, Carroll RC. A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med. 2004 May;143(5):301-9.
Cowan SM, Bartges JW, Gompf RE, Hayes JR, Moyers TD, Snider CC, Gerard DA, Craft RM, Muenchen RA, Carroll RC. Giant platelet disorder in the Cavalier King Charles Spaniel. Exp Hematol. 2004 Apr;32(4):344-50.
Chavez JJ, Weatherall JS, Strevels SM, Liu F, Snider CC, Carroll RC. Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery. J Clin Anesth. 2004 Feb;16(1):7-10.
Mobley JE, Bresee SJ, Wortham DC, Craft RM, Snider CC, Carroll RC. Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization. Am J Cardiol. 2004 Feb 15;93(4):456-8.
Chavez JJ, Foley DE, Snider CC, Howell JC, Cohen E, Muenchen RA, Carroll RC. A novel thrombelastograph tissue factor/kaolin assay of activated clotting times for monitoring heparin anticoagulation during cardiopulmonary bypass. Anesth Analg. 2004 Nov;99(5):1290-4
Carroll RC, Craft RM, Chavez JJ, Snider CC, Bresee SJ, Cohen E. A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid. J Lab Clin Med. 2005 Jul;146(1):30-5.
Craft RM, Chavez JJ, Snider CC, Muenchen RA, Carroll RC. Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients. J Lab Clin Med. 2005 Jun;145(6):309-15.
Carroll RC, Owers RL, Elder RF, Hennessey MD, Patteson SK, Snider CC, Muenchen RA. Lack of thrombopoietin potentiation of platelet collagen activation in the first trimester is associated with preeclampsia. Thromb Res. 2005;116(1):51-4.
Carroll RC, Owers RL, Elder RF, Hennessey MD, Patteson SK, Snider CC, Hammer NL, Quinn MP, Muenchen RA. Prospective evaluation of platelet B2 bradykinin and thrombopoietin receptor levels from preeclamptic compared to non-preeclamptic pregnancy patients. Thromb Res. 2006;117(5):551-6.
Carroll RC, Chavez JJ, Snider CC, Meyer DS, Muenchen RA. Correlation of perioperative platelet function and coagulation tests with bleeding after cardiopulmonary bypass surgery. J Lab Clin Med. 2006 Apr;147(4):197-204.
Carroll RC, Chavez JJ, Simmons JW, Snider CC, Wortham DC, Bresee SJ, Cohen E. Measurement of patients' bivalirudin plasma levels by a thrombelastograph ecarin clotting time assay: a comparison to a standard activated clotting time. Anesth Analg. 2006 May;102(5):1316-9.
Carroll RC, Craft RM, Whitaker GL, Snider CC, Kirby RK, Elder RF, Hennessey MD. Thrombelastography monitoring of resistance to enoxaparin anticoagulation in thrombophilic pregnancy patients. Thromb Res. 2007;120(3):367-70.
Patteson SK, Snider CC, Meyer DS, Enderson BL, Armstrong JE, Whitaker GL, Carroll RC. The consequences of high-risk behaviors: trauma during pregnancy. J Trauma. 2007 Apr;62(4):1015-20.
Carroll RC, Craft RM, Chavez JJ, Snider CC, Kirby RK, Cohen E. Measurement of functional fibrinogen levels using the Thrombelastograph. J Clin Anesth. 2008 May;20(3):186-90.
The University of Tennessee Graduate School of Medicine
Office of the Dean
1924 Alcoa Highway, U94
Knoxville, TN 37920
Phone: (865) -305-9290 or
(800)-596-7249
Fax: (865) 305-6819