The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Radiology

David Blevins, PhD

Assistant Professor

Research Focus

Synthesize and develop fluorine-18 labeled nootropic compounds for potential imaging of the brain. Assist in the setup and development of a GMP radiopharamacy to manufacture PET drugs for clinical trials. Develop new ideas to expand the field of radiochemistry and molecular imaging. Invent new technologies to be utilized in radiosynthesis and molecular imaging applications. Submit Invention disclosures to protect intellectual property.

Education

Graduate School
University of Tennessee, Knoxville, TN, 2012
Ph.D. Organic Chemistry

Undergraduate School

The University of Virginia's College at Wise, Wise,VA, 2003
B.A. Chemistry, Minor: Biology

Current Publications

Blevins DW, Rigney GH, Fang MY, Akula MR, Osborne DR.
Novel methods for the quantification of toxic, residual phase transfer catalyst in fluorine-18 labeled radiotracers. Nuclear Medicine and Biology. 2019 Jul 22. [Epub ahead of print]

Akula MR, Blevins D, Kabalka GW, Osborne D.
Synthesis of N-[4-(2'-[18F]fluoroalkyloxybenzoyl)]- and N-[4-methoxy-3[123I]iodobenzoyl]-pyrrolidin-2-ones as potential brain imaging agents. Heterocycles. 2018;97(2):1226-1236. Epub 2018 Jun 12.

Blevins DW, Kabalka GW, Osborne DR, Akula MR.
Effect of added Cu(OTf)2 on the Cu(OTf)2(Py)4-mediated radiofluorination of benzoyl and phthaloylglycinates. Natural Science. 2018 Mar;10(3):83524.

Current Presentations

Akula MR, Blevins D, Kabalka G, Osborne DR. An improved synthesis of 4-(4-[F-18]fluorophenyl)piracetam, a PET agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne D. Novel pyridinyl quarternary ammonium salts as precursors of radiofluorination. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 4-(4-[I-123]Iodophenyl)piracetam, a potential SPECT agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 6-[F-18]Fluoropyridine-3-carbaldehyde-O-[4-(2,5-dioxo-2,5-dihydropyrrol-1-yl)butyl and pentyl]oximes, Novel thiol reactive bifunctional agents for peptide labeling. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula M, Blevins D, Kabalka G, Osborne D. Microfluidic synthesis of aniracetam analogues as potential PET brain imaging agents. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Blevins D, Akula M, Kabalka G, Osborne D. Synthesis of 4-(4-[18F]fluorophenylpiracetam, a potential PET agent for Parkinson’s disease. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Akula M, Blevins D, Kabalka G, Osborne D. Improved Microfluidic Synthesis of 1-(2-[18F]fluoroethoxy)-4-[2-{4-(methylsulfonyl) phenyl}cyclopent-1-enyl]benzene, a potential COX-2 inhibitor to characterize solid tumors. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

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