The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Radiology

Murthy R. Akula, PhD

Associate Professor

Research Focus

Synthetic Approaches towards Natural Products and Biologically Active Compounds; Drug Design and Structure Activity Relationship Studies; Asymmetric Synthesis; Synthesis of Radioactive Tracers and Diagnostic Nuclear Medicine

Education

Graduate School
M.Sc., Banaras Hindu University, Banaras, India
Ph.D., Organic Chemistry, Indian Institute of Science, Bangalore, India

Current Publications

Akula MR, Blevins D, Kabalka GW, Osborne D.
Synthesis of N-[4-(2'-[18F]fluoroalkyloxybenzoyl)]- and N-[4-methoxy-3[123I]iodobenzoyl]-pyrrolidin-2-ones as potential brain imaging agents. Heterocycles. 2018 Jun 12;97. [Epub ahead of print]

Blevins DW, Kabalka GW, Osborne DR, Akula MR.
Effect of added Cu(OTf)2 on the Cu(OTf)2(Py)4-mediated radiofluorination of benzoyl and phthaloylglycinates. Natural Science. 2018 Mar;10(3):83524.

Moore TM, Akula MR, Collier L, Tamagnan G, Papin C, Alagille D, Kabalka GW.
Effect of leaving group substituents on the microfluidic synthesis of [18F]3-Fluoro-5-[(Pyridin- 3-YL)Ethynyl]benzonitrile ([18F]FPEB). Heterocycles. 2017;95(2):807-815.

Akula MR, Marepally SR, Collier LT, Kabalka WG.
Semi-automated synthesis of [F-18]FBAM, a thiol reactive prosthetic group, using continuous flow chemistry. International Journal of Organic Chemistry. 2016 Sep;6(3):177-185.

Akula M, Blevins D, Kabalka G.
Continuous flow microfluidic chemistry: Synthesis of [18F]-3-fluoro-2-(4-((2-nitro-1h-imidazol-1-yl)methyl)-1h-1,2,3-Triazol-1-yl)propan-1-ol, [18F]F-HX4, a potent hypoxia agent. Heterocycles. 2016;93(2):745-754.

Moore TM, Akula MR, Kabalka GW.
Fluorine-18 Radiochemistry: A Novel Thiol-Reactive Prosthetic Group, [18F]FBAMPy. Natural Science. 2016 Jan;8:1-7.

Current Presentations

Akula M, Blevins D, Kabalka G, Osborne D. Microfluidic synthesis of aniracetam analogues as potential PET brain imaging agents. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Blevins D, Akula M, Kabalka G, Osborne D. Synthesis of 4-(4-[18F]fluorophenylpiracetam, a potential PET agent for Parkinson’s disease. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Akula M, Blevins D, Kabalka G, Osborne D. Improved Microfluidic Synthesis of 1-(2-[18F]fluoroethoxy)-4-[2-{4-(methylsulfonyl) phenyl}cyclopent-1-enyl]benzene, a potential COX-2 inhibitor to characterize solid tumors. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Osborne D Stuckey A, Kennel S, Blevins D, Akula MR. Fluoroaniracetam: Initial biodistribution and characterization of a new brain imaging agent. Presented at Society Of Nuclear Medicine And Molecular Imaging Annual Meeting; 2015 Jun 6-10; Baltimore, MD.

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