The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Radiology

Murthy R. Akula, PhD

Associate Professor

Research Focus

Synthetic Approaches towards Natural Products and Biologically Active Compounds; Drug Design and Structure Activity Relationship Studies; Asymmetric Synthesis; Synthesis of Radioactive Tracers and Diagnostic Nuclear Medicine

Education

Graduate School
M.Sc., Banaras Hindu University, Banaras, India
Ph.D., Organic Chemistry, Indian Institute of Science, Bangalore, India

Current Publications

Akula MR, Blevins D, Kabalka GW, Osborne D.
Synthesis of N-[4-(2'-[18F]fluoroalkyloxybenzoyl)]- and N-[4-methoxy-3[123I]iodobenzoyl]-pyrrolidin-2-ones as potential brain imaging agents. Heterocycles. 2018;97(2):1226-1236. Epub 2018 Jun 12.

Blevins DW, Kabalka GW, Osborne DR, Akula MR.
Effect of added Cu(OTf)2 on the Cu(OTf)2(Py)4-mediated radiofluorination of benzoyl and phthaloylglycinates. Natural Science. 2018 Mar;10(3):83524.

Moore TM, Akula MR, Collier L, Tamagnan G, Papin C, Alagille D, Kabalka GW.
Effect of leaving group substituents on the microfluidic synthesis of [18F]3-Fluoro-5-[(Pyridin- 3-YL)Ethynyl]benzonitrile ([18F]FPEB). Heterocycles. 2017;95(2):807-815.

Akula MR, Marepally SR, Collier LT, Kabalka WG.
Semi-automated synthesis of [F-18]FBAM, a thiol reactive prosthetic group, using continuous flow chemistry. International Journal of Organic Chemistry. 2016 Sep;6(3):177-185.

Current Presentations

Akula MR, Blevins D, Kabalka G, Osborne DR. An improved synthesis of 4-(4-[F-18]fluorophenyl)piracetam, a PET agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne D. Novel pyridinyl quarternary ammonium salts as precursors of radiofluorination. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 4-(4-[I-123]Iodophenyl)piracetam, a potential SPECT agent for Parkinson’s disease. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula MR, Blevins D, Kabalka G, Osborne DR. Synthesis of 6-[F-18]Fluoropyridine-3-carbaldehyde-O-[4-(2,5-dioxo-2,5-dihydropyrrol-1-yl)butyl and pentyl]oximes, Novel thiol reactive bifunctional agents for peptide labeling. Presented at International Symposium of Radiopharmaceutical Society; 2019 May 25-31; Beijing, China.

Akula M, Blevins D, Kabalka G, Osborne D. Microfluidic synthesis of aniracetam analogues as potential PET brain imaging agents. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Blevins D, Akula M, Kabalka G, Osborne D. Synthesis of 4-(4-[18F]fluorophenylpiracetam, a potential PET agent for Parkinson’s disease. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

Akula M, Blevins D, Kabalka G, Osborne D. Improved Microfluidic Synthesis of 1-(2-[18F]fluoroethoxy)-4-[2-{4-(methylsulfonyl) phenyl}cyclopent-1-enyl]benzene, a potential COX-2 inhibitor to characterize solid tumors. Presented at International Symposium on Radiopharmaceutical Sciences (Invited Lecture); 2017 May 14-19; Dresden, Germany.

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