The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Radiology

Murthy R. Akula, PhD

Associate Professor

Research Focus

Synthetic Approaches towards Natural Products and Biologically Active Compounds; Drug Design and Structure Activity Relationship Studies; Asymmetric Synthesis; Synthesis of Radioactive Tracers and Diagnostic Nuclear Medicine

Education

Graduate School
M.Sc., Banaras Hindu University, Banaras, India
Ph.D., Organic Chemistry, Indian Institute of Science, Bangalore, India

Current Publications

Akula MR, Marepally SR, Collier LT, Kabalka WG.
Semi-automated synthesis of [F-18]FBAM, a thiol reactive prosthetic group, using continuous flow chemistry. International Journal of Organic Chemistry. 2016 Sep;6(3):177-185.

Moore TM, Akula MR, Kabalka GW.
Fluorine-18 Radiochemistry: A Novel Thiol-Reactive Prosthetic Group, [18F]FBAMPy. Natural Science. 2016 Jan;8:1-7.

Zheng MQ, Collier L, Bois F, Kelada OJ, Hammond K, Ropchan J, Akula MR, Carlson DJ, Kabalka GW, Huang Y.
Synthesis of [(18)F]FMISO in a flow-through microfluidic reactor: Development and clinical application. Nuclear Medicine and Biology. 2015 Jun;42(6):578-84.

Current Presentations

Akula M, Blevins D, Kabalka G, Osborne D. Continuous flow microfluidic chemistry: Synthesis of [F-18]Fluoro analogues of aniracetam as brain imaging agents. Presented at 250 th Annual Meeting of the American Chemical Chemistry; 2015 Aug 16-20; Boston, MA.

Osborne D, Stuckey A, Kennel S, Blevins D, Akula M. Fluroaniracetam: Initial biodistribution and characterization of a new brain imaging agent. Presented at Society of Nuclear Medicine and Molecular Imaging Annual Meeting; 2015 Jun 6-10; Baltimore, MD.

Akula M, Blevins D, Kabalka G, Osborne D. Synthesis of a new thiol reactive bifunctional agent [18F]FPyAM using microfluidic system. Presented at The 21st International Symposium on Radiopharmaceutical Sciences; 2015 May 26-31; Columbia, MO.

Akula M, Blevins D, Kabalka G, Osborne D. Synthesis of N-[4-(2’-[18F]fluoroethyloxybenzoyl)]pyrrolidin-2-one: A potential new brain imaging agent. Presented at The 21st International Symposium on Radiopharmaceutical Sciences; 2015 May 26-31; Columbia, MO.

Akula M, Blevins D, Kabalka G, Osborne D. Synthesis of [123I]Iodoaniracetam, a SPECT agent for brain imaging. Presented at The 21st International Symposium on Radiopharmaceutical Sciences; 2015 May 26-31; Columbia, MO.

Akula M, Blevins D, Kabalka G, Osborne D. Microfluidic Synthesis of N-[6-(4-[18F]fluorobenzylidine)aminooxyhexyl]maleimide. Presented at The 21st International Symposium on Radiopharmaceutical Sciences; 2015 May 26-31; Columbia, MO.

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