Publications
Williams, A.D., M. Sega, M. Chen, I. Kheterpal, M. Geva, V. Berthelier, D.T. Kaleta, K.D. Cook and R. Wetzel (2005) "Structural properties of A ß protofibrils stabilized by a small molecule." PNAS. 102(20): 7115-7120.
Whitttemore, N.A., R. Mishra, I. Kheterpal, A.D. Williams. R. Wetzel and E.H. Serpersu (2005) "Hydrogen-Deuterium (H/D) Exchange Mapping of Abeta (1)(-)(40) Amyloid Fibril Secondary Structure Using Nuclear Magnetic Resonance Spectroscopy." Biochemistry, 22;44(11): 4434-4441.
Guo, J.T., R. Wetzel and Y. Xu (2004) "Molecular modeling of the core of Abeta amyloid fibrils." Proteins, 57(2): 357-64.
Thakur, A.K., W. Yang and R. Wetzel (2004) "Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor." FASEB J. 18(7): 923-925.
Venkatraman, P., R. Wetzel, M. Tanaka, N. Nukina and A.L. Goldberg (2004) "Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polygluatime-containing proteins." Mol. Cell. 14(1): 95-104.
Cannon, M. J., A. D. Williams, R. Wetzel, and D. G. Myszka (2004) “Kinetic analysis of beta-amyloid fibril elongation.” Anal. Biochem. 328: 67-75.
Wetzel, R. (2004) "Amyloid" Encyclopedia of Biological Chemistry, 1: 99-104.
Shivaprasad, S. and R. Wetzel. (2004) "An Intersheet Packing Interaction in Aß Fibrils Mapped by Disulfide Cross-Linking." Biochemistry, 43: (49)15310-15317.
O'Nuallain, B., A. Williams, P. Westermark and R. Wetzel (2004) "Seeding Specificity in Amyloid Growth Induced by Heterologous Fibrils." J. Biol. Chem. 279: 17490-17499
Williams, A., E. Portelius, I. Kheterpal, J. Guo, K. Cook, Y. Xu and R. Wetzel (2004) "Mapping Aß Amyloid Fibril Secondary Structure Using Scanning Proline Mutagenesis." J. Mol. Biol. 335: 833-842.
Kheterpal, I., H. Lashuel, D. Hartley, T. Walz, P. Lansbury, Jr. and R. Wetzel. (2003) "Aß Protofibrils Possess a Stable Core Structure Resistant to Hydrogen Exchange" Biochemistry, 42:14092-14098
Kheterpal, I., R. Wetzel and K.D. Cook. (2003) "Enhanced correction methods for hydrogen exhange-mass spectrometric studies of amyloid fibrils" Prot. Sci. 12:635-643
Thakar, A. and R. Wetzel. (2002) "Mutational analysis of the structural organization of polyglutamine aggregates" Proc. Natl. Acad. Sci. (USA) 99:17014-17019
Yang, W., J. R. Dunlap, R. B. Andrews, and R. Wetzel. (2002) "Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells" Human Molecular Genetics. 11: 2905-2917
Chen, S. , F.A. Ferrone, and R. Wetzel. (2002) " Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation." Proc. Natl. Acad. Sci. (USA) 99: 11884-11889.
Chen, S. , V. Berthelier, B. Hamilton, B. O'Nuallain, and R. Wetzel. (2002) " Amyloid-like features of polyglutamine aggregates and their assembly kinetics." Biochem. 41: 7391-7399.
O'Nuallain, B. and R. Wetzel (2002) "Conformational Abs recognizing a generic amyloid fibril epitope." Proc. Natl. Acad. Sci. (USA) 99: 1485-1490.
Kheterpal, I., A. Williams, C. Murphy, B. Bledsoe, and R. Wetzel (2001) "Structural features of the Aß amyloid fibril elucidated by limited proteolysis." Biochem. 40: 11557-11767.
Chen, S. and R. Wetzel. (2001) " Solubilization and disaggregation of polyglutamine peptides." Prot. Sci. 10: 887-891.
Berthelier, V., J. B. Hamilton, S. Chen and R. Wetzel. (2001) "A microtiter plate assay for polyglutamine aggregate extension." Anal. Biochem. 295: 227-236.
Chen, S., V. Berthelier, W. Yang and R. Wetzel. (2001) "Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity." J. Mol. Biol. 311: 173-182.
Kheterpal, I., S. Zhou, K. D. Cook and R. Wetzel. (2000) "Aß amyloid fibrils possess a core structure highly resistant to hydrogen exchange." Proc. Natl. Acad. Sci. (USA) 97: 13597-13601.
Book Chapters and Reviews
Wetzel, R. (2005) "Protein Folding and Aggregation in the Expanded Polyglutamine Repeat Diseases." Protein Folding
Handbook, Part II. Wiley-VCH, 1200-1244.
Wetzel, R. (2002) "Ideas of Order for Amyloid Fibril Structure." Structure 10, 1031-1036.
Berthelier, V. and R. Wetzel (2002) " An assay for characterizing the in vitro kinetics of polyglutamine aggregation." Methods in Molecular Medicine: Neurogenetics. N. T. Potter, Ed. New York, Humana Press (In press).
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