Valerie Berthelier, Ph.D.
Assistant Professor
vberthel@mc.utmck.edu
B.S. Biochemistry,
University of Paris, France, 1991
M.S. Biochemistry,
University of Paris, France, 1992
Diploma of Graduate Study in Molecular Biophysics, University of Paris, France, 1993
Ph.D. Molecular Biophysics,
University of Paris, France, 1998,
Dissertation: "The CD38 ecto-enzyme - Enzymatic function, molecular conformation, and cellular role."
Publications Chen, S. , V. Berthelier, B. Hamilton, B. O'Nuallain, and R. Wetzel. (2002) " Amyloid-like features of polyglutamine aggregates and their assembly kinetics." Biochem. 41: 7391-7399.
Berthelier, V., J. B. Hamilton, S. Chen and R. Wetzel (2001) "A microtiter plate assay for polyglutamine aggregate extension." Anal. Biochem. 295: 227-236.
Chen, S., V. Berthelier, W. Yang and R. Wetzel (2001) "Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity." J. Mol Biol. 311: 173-182.
Berthelier, V., J. Laboureau, G. Boulla, F. Schuber and P. Deterre (2000) "Probing ligand-induced conformational changes of human CD38." Eur. J. Biochem. 267: 3056-3064.
Berthelier, V., J. M. Tixier, H. Muller-Steffner, F. Schuber and P. Deterre (1998) "Human CD38 is an authentic NAD(P)+ glycohydrolase." Biochem J. 330: 1383-1390.
Deterre, P., L. Gelman, H. Gary-Gouy, C. Arrieumerlou, V. Berthelier, J. M. Tixier, S. Ktorza, J. Goding, C. Schmitt and G. Bismut (1996) "Coordinated regulation in human T cells of nucleotide-hydrolyzing ecto-enzyme activities, including CD38 and PC-1. Possible role in the recycling of nicotinamide adenine dinucleotide metabolites." J. Immunol. 157: 1381-1388.
Berthelier, V. F. Malavasi, G. Bismuth, C. Schmitt and P. Deterre (1996) "Report on the 2nd International CD38 workshop." Res. Immunol. 147: 407-411.
Berthelier, V., A. Laigle, B. Jolles, and L. Chinsky (1995) "Distortion after monofunctional alkylation by mitomycin C of a dodecamer containing its major binding site." J. Biomol. Struct. Dyn. 12: 899-910.
Book Chapters
Berthelier, V. and R. Wetzel (2002) "An assay for characterizing the in vitro kinetics of polyglutamine aggregation." Methods in Molecular Medicine: Neurogenetics. N. T. Potter, Ed. New York, Humana Press (In press).
Deterre, P., V. Berthelier, B. Bauvois, A. Dalloul, F. Schuber and F. Lund (2000) "CD38 in T- and B-cell functions." Chemical Immunology: Human CD38 and Related Molecules K. Mehta and F. Malavasi, Eds. Karger, Basal, Switzerland. 75: 146-168.
Research Project
Development of a microtiter plate assay to study biophysical properties of synthetic polyglutamine aggregates. Based on the ability of polyglutamine aggregates to be extended by polyglutamine monomers, we have developed an assay to study the biophysical properties of these aggregates. This assay is also used to screen potential inhibitors of polyglutamine aggregation.
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