The Department of Medical Genetics Faculty
James Pai-Fun Chen, PhD
Professor Emeritus
Education
BS, Houghton (N.Y.) Coll., 1955
MS, St. Lawrence U., 1957
PhD, Pa. State U., 1961
Professional Experience
Associate Professor- Houghton College, 1960-64
Research Associate-College of Medicine, University of Vermont, Burlington, 1964-65
Research Associate-School of Medicine SUNY, Buffalo, 1965-68
Assistant Professor- University of Texas Med. Br., Galveston, 1968-75
Senior Research Associate-NASA/Johnson Space Center, Houston, 1975-76
Research Associate Professor-University of Tennessee Memorial Research Center, Knoxville, Tennessee, 1976-78
Associate Professor- College of Medicine, University of Tennessee, 1978-84
Professor, Graduate School fo Medicine, 1984-.
Texas affiliate American Heart Association, Austin, 1974-76
Co-investigator Spacelab I project, Johnson Space Center, Houston, 1976-83
Visiting Professor- Trnovo Hospital Internal Medicine, Ljubljana, Yugoslavia, 1985.
Organizations and Affiliations
Contributes approximately 50 articles to professional journals including, Thrombosis and Haemostasis.
Grantee Robert Welch Foundation, 1970-74,
Ortho Research Foundation, 1971-75,
NIH, 1975-82,
American Heart Association Texas affiliate, 1969-72, 74-75, American Heart Association Tennessee affiliate, 1984-85, 89-90
U.S. Army Med. Rsch., 1988-91.
Fellow International Society of Hematology
Member, American Association of Immunologists,
American Society of Biochemistry and Molecular Biology, International Society of Thrombosis and Haemostasis, International Fibrinogen Research Society, International Society of Fibrinolysis Proteolysis
American Board of Bioanalysis -Clinical Lab Director
Achievements
Achievements include research in thrombosis and hemostasis; discovery of additional proteolytic fragmentation in the high temperature trypsin cleavage of human IgM; development of a radioimmunoassay for fragment E-neoantigen and applied it to the clinical assay of hypercoagulable state; discovered evidence of the coagulopathy in Pichinde virus-infected guinea pigs; establishment of blood tests to monitor trauma patients for thromboembolism; recognized that hypercoagulability in preterm infants with intraventricular hemorrhage is associated with fibrinolytic shutdown; ascertained that complement and cytokines are responsible for antibody-mediated hypercoagulability in the anti-T-cell therapy of transplantation.
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