Conformational Diseases and Therapeutics Research - Representative Publications

Berthelier, V. and Wetzel, R. (2006) Screening for Modulators of Aggregation with a Microplate Elongation Assay, Methods in Enzymology, 413:313-25.

Osmand, A.P., Berthelier, V. and Wetzel R. (2006) Imaging polyglutamine deposits in brain tissue. Methods in Enzymology, 412: 106-122

Williams, A.D., Sega, M., Chen, M., Ketherpal, I., Geva, M., Berthelier, V., Kaleta, D., Cook, K.D. and Wetzel, R. (2005) Structural properties of Abeta protofibrils stabilized by a small molecule. Proceeding National Academy of Sciences USA,102:71115-71120

Berthelier, V. and Wetzel, R. (2003). An assay for characterizing the in vitro kinetics of polyglutamine aggregation.  Methods in Molecular Medicine: Neurogenetics, 217:293-303

Chen, S., Berthelier, V., Hamilton, J.B., O’Nuaillan, B., and Wetzel, R. (2002). Amyloid-like features of polyglutamine aggregates and their assembly kinetics.  Biochemistry, 41:7391-7399

Berthelier, V., Hamilton, J.B., Chen, S. and Wetzel, R. (2001). A microtiter plate assay for polyglutamine aggregate extension. Analytical Chemistry, 295:227-236

Chen, S., Berthelier, V., Yang, W. and Wetzel, R. (2001). Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity. Journal of Molecular Biology, 311:173-182