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Work in our laboratory focuses on how growth and death of breast and ovarian cancer cells is regulated by estrogens and chemotherapy agents like paclitaxel. Specifically we study the signal transduction pathways through which estrogens and paclitaxel regulate the cell cycle and apoptosis in cultured human breast and ovarian cancer cells. Our studies may in the future lead to identification of cellular targets in cancer cells which may prevent growth and or induce death in cancer cells.
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