Robert H. Cole Endowed Professor of Neuroscience
Co-Director of Anesthesiology Research
Anesthesia Research Division
My research program aims to help understand the cellular and neurochemical mechanisms regulating states of consciousness and state-dependent changes in physiology.
The goals of Lydic's research are elucidating the mechanisms by which sleep, opioids, and volatile anesthetics modulate pain and depress breathing and arousal. The evolutionary perspective and current data support the view that neurons generating sleep and wakefulness preferentially modulate the ability of opioids, hypnotics, and anesthetics to alter pain, behavioral affect, and states of waking consciousness.
External Advisory Council Chairman, National Space Biomedical Research Institute
Kass RE, Lydic RB: Preface. In: Dynamic Neuroscience: Statistics, Modeling, and Control, Cham: Springer, 2017.
Hillman D, Kaw R, Lydic R: Sleep and anesthesia: Different states with shared pathophysiological traits. In: Sleep Disorders Medicine, New York: Springer, 143-151, 2017.
Lydic R, Keifer JC, Baghdoyan HA, Craft R, Angel C. Principles and Practice of Sleep Medicine, 6th Edition. New York: Elsevier; c2016. Chapter 24, Opiate action on sleep and breathing; p. 260-269.
Lydic RB, Baghdoyan HA. Sleep and Pain. Washington DC: IASP, c2015. Chapter 5, Neurochemical mechanisms mediating opioid-induced REM sleep disruption; p. 101-122.
Bourdon AK, Spano GM, Marshall W, Bellesi M, Tononi G, Serra PA, Baghdoyan HA, Lydic R, Campagna SR, Cirelli C.
Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep. Scientific Reports. 2018 Jul 25;8(1):11225.
McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Karlstad MD, Lydic R.
Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. Sleep. 2018 Aug 11. [Epub ahead of print]
Angel C, Glovak ZT, Alami W, Mihalko S, Price J, Jiang Y, Baghdoyan HA, Lydic R.
Buprenorphine depresses respiratory variability in obese mice with altered leptin signaling. Anesthesiology. 2018 May;128(5):984-991.
Lydic R, Baghdoyan HA, May AL.
Neurochemistry of anesthetic states. Methods in Enzymology. 2018;603:237-255. Epub 2018 Mar 5.
Glovak Z, Mihalko S, Baghdoyan HA, Lydic R.
Leptin status alters buprenorphine-induced antinociception in obese mice with dysfunctional leptin receptors. Neuroscience Letters. 2017 Nov 1;660:29-33. Epub 2017 Sep 8.
Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R.
RGS proteins and G-alpha-i2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. Sleep. 2016 Feb 1;39(2):393-404. Epub 2015 Nov 6.
McLain JM, Cooley CR, Brandi JP, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in obesity-induced type 2 diabetic mouse model. Presented at 41st Annual Conference on Shock; 2018 Jun 9-12; Scottsdale, AZ.
McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in a diabetic mouse. Presented at Society for Neuroscience; 2017 Nov 15-18; Washington, DC.
Baer A, Bourdon AK, Spano G, Bellesi M, Bradley A, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Campagna SR, Lydic R. Metabolomic analysis of microdialysis samples from the frontal association cortex of C57BL/6J mouse during isoflurane anesthesia. Presented at Experimental Biology: American Physiological Society; 2017 Apr 22-26; Chicago, IL.
Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Assessing the effects of sleep and wakefulness on the metabolome of mouse cortex using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.
Mihalko S, Glovak Z, Wiles KT, Angel C, Johnson JE, Baghdoyan HA, Lydic R. Buprenorphine-induced antinociception varies as a function of leptin status in obese mice. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.
Angel CL, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Buprenorphine-induced respiratory depression varies as a function of leptin-related genotype in normal weight and obese mice. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Untargeted metabolomics reveal state-dependent neurochemical changes in frontal association (FrA) and motor cortex (M1) of C57Bl/6J (B6) mouse. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Angel C, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Sex, leptin status, and obesity modulate buprenorphine-induced respiratory depression in mice. Presented at American Physiological Society: Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender; 2015 Nov 17-20; Annapolis, MD.Top
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