The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Anesthesiology

Ralph Lydic, PhD

Professor
Co-Director of Anesthesiology Research
Anesthesia Research Division

Research Focus

My research program aims to help understand the cellular and neurochemical mechanisms regulating states of consciousness and state-dependent changes in physiology.

Research Statement

The goals of Lydic's research are elucidating the mechanisms by which sleep, opioids, and volatile anesthetics modulate pain and depress breathing and arousal.  The evolutionary perspective and current data support the view that neurons generating sleep and wakefulness preferentially modulate the ability of opioids, hypnotics, and anesthetics to alter pain, behavioral affect, and states of waking consciousness.

Honors

Professional Affiliation

External Advisory Council Chairman, National Space Biomedical Research Institute

Book Chapter Published

Lydic R, Keifer JC, Baghdoyan HA, Craft R, Angel C. Principles and Practice of Sleep Medicine, 6th Edition. New York: Elsevier; c2016. Chapter 24, Opiate action on sleep and breathing; p. 260-269.

Lydic RB, Baghdoyan HA. Sleep and Pain. Washington DC: IASP, c2015. Chapter 5, Neurochemical mechanisms mediating opioid-induced REM sleep disruption; p. 101-122.

Current Publications

Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R.
RGS proteins and G-alpha-i2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. Sleep. 2016 Feb 1;39(2):393-404. Epub 2015 Nov 6.

Current Presentations

Angel CL, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Buprenorphine-induced respiratory depression varies as a function of leptin-related genotype in normal weight and obese mice. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.

Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Untargeted metabolomics reveal state-dependent neurochemical changes in frontal association (FrA) and motor cortex (M1) of C57Bl/6J (B6) mouse. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.

Angel C, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Sex, leptin status, and obesity modulate buprenorphine-induced respiratory depression in mice. Presented at American Physiological Society: Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender; 2015 Nov 17-20; Annapolis, MD.

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