Co-Director of Anesthesiology Research
Anesthesia Research Division
Neurochemical regulation of sleep and wakefulness, mechanisms of general anesthesia, mechanisms underlying the relationship between sleep disruption and psychiatric disorders.
My research program aims to identify the neurochemical mechanisms and brain regions that regulate behavioral states such as sleep, wakefulness, and anesthesia. The goals of my laboratory are to identify overlapping neuronal circuits regulating the interactions between sleep, anesthesia, mood, cognition, and pain. The work focuses on acetylcholine, GABA, and hypocretin/orexin as neurotransmitters, and the pontine reticular formation, basal forebrain, and prefrontal cortex as brain regions important for behavioral state control.
Lydic R, Keifer JC, Baghdoyan HA, Craft R, Angel C. Principles and Practice of Sleep Medicine, 6th Edition. New York: Elsevier; c2016. Chapter 24, Opiate action on sleep and breathing; p. 260-269.
Lydic RB, Baghdoyan HA. Sleep and Pain. Washington DC: IASP, c2015. Chapter 5, Neurochemical mechanisms mediating opioid-induced REM sleep disruption; p. 101-122.
Bourdon AK, Spano GM, Marshall W, Bellesi M, Tononi G, Serra PA, Baghdoyan HA, Lydic R, Campagna SR, Cirelli C.
Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep. Scientific Reports. 2018 Jul 25;8(1):11225.
McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Karlstad MD, Lydic R.
Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. Sleep. 2018 Aug 11. [Epub ahead of print]
Angel C, Glovak ZT, Alami W, Mihalko S, Price J, Jiang Y, Baghdoyan HA, Lydic R.
Buprenorphine depresses respiratory variability in obese mice with altered leptin signaling. Anesthesiology. 2018 May;128(5):984-991.
Lydic R, Baghdoyan HA, May AL.
Neurochemistry of anesthetic states. Methods in Enzymology. 2018;603:237-255. Epub 2018 Mar 5.
Glovak Z, Mihalko S, Baghdoyan HA, Lydic R.
Leptin status alters buprenorphine-induced antinociception in obese mice with dysfunctional leptin receptors. Neuroscience Letters. 2017 Nov 1;660:29-33. Epub 2017 Sep 8.
Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R.
RGS proteins and G-alpha-i2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. Sleep. 2016 Feb 1;39(2):393-404. Epub 2015 Nov 6.
McLain JM, Cooley CR, Brandi JP, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in obesity-induced type 2 diabetic mouse model. Presented at 41st Annual Conference on Shock; 2018 Jun 9-12; Scottsdale, AZ.
McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Lydic R, Karlstad MD. Sleep fragmentation delays wound healing in a diabetic mouse. Presented at Society for Neuroscience; 2017 Nov 15-18; Washington, DC.
Baer A, Bourdon AK, Spano G, Bellesi M, Bradley A, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Campagna SR, Lydic R. Metabolomic analysis of microdialysis samples from the frontal association cortex of C57BL/6J mouse during isoflurane anesthesia. Presented at Experimental Biology: American Physiological Society; 2017 Apr 22-26; Chicago, IL.
Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Assessing the effects of sleep and wakefulness on the metabolome of mouse cortex using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.
Mihalko S, Glovak Z, Wiles KT, Angel C, Johnson JE, Baghdoyan HA, Lydic R. Buprenorphine-induced antinociception varies as a function of leptin status in obese mice. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.
Angel CL, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Buprenorphine-induced respiratory depression varies as a function of leptin-related genotype in normal weight and obese mice. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Untargeted metabolomics reveal state-dependent neurochemical changes in frontal association (FrA) and motor cortex (M1) of C57Bl/6J (B6) mouse. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Angel C, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Sex, leptin status, and obesity modulate buprenorphine-induced respiratory depression in mice. Presented at American Physiological Society: Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender; 2015 Nov 17-20; Annapolis, MD.Top
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