The University of Tennessee Graduate School of Medicine, Knoxville



The Department of Anesthesiology

Helen A. Baghdoyan, PhD

Professor
Co-Director of Anesthesiology Research
Anesthesia Research Division

Research Focus

Neurochemical regulation of sleep and wakefulness, mechanisms of general anesthesia, mechanisms underlying the relationship between sleep disruption and psychiatric disorders.

Research Statement

My research program aims to identify the neurochemical mechanisms and brain regions that regulate behavioral states such as sleep, wakefulness, and anesthesia.  The goals of my laboratory are to identify overlapping neuronal circuits regulating the interactions between sleep, anesthesia, mood, cognition, and pain.  The work focuses on acetylcholine, GABA, and hypocretin/orexin as neurotransmitters, and the pontine reticular formation, basal forebrain, and prefrontal cortex as brain regions important for behavioral state control.

Honors

Book Chapter Published

Lydic R, Keifer JC, Baghdoyan HA, Craft R, Angel C. Principles and Practice of Sleep Medicine, 6th Edition. New York: Elsevier; c2016. Chapter 24, Opiate action on sleep and breathing; p. 260-269.

Lydic RB, Baghdoyan HA. Sleep and Pain. Washington DC: IASP, c2015. Chapter 5, Neurochemical mechanisms mediating opioid-induced REM sleep disruption; p. 101-122.

Current Publications

Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R.
RGS proteins and G-alpha-i2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. Sleep. 2016 Feb 1;39(2):393-404. Epub 2015 Nov 6.

Current Presentations

Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Assessing the effects of sleep and wakefulness on the metabolome of mouse cortex using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.

Mihalko S, Glovak Z, Wiles KT, Angel C, Johnson JE, Baghdoyan HA, Lydic R. Buprenorphine-induced antinociception varies as a function of leptin status in obese mice. Presented at Society for Neuroscience 46th Annual Meeting; 2016 Nov 12-16; San Diego, CA.

Angel CL, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Buprenorphine-induced respiratory depression varies as a function of leptin-related genotype in normal weight and obese mice. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.

Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Untargeted metabolomics reveal state-dependent neurochemical changes in frontal association (FrA) and motor cortex (M1) of C57Bl/6J (B6) mouse. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.

Angel C, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Sex, leptin status, and obesity modulate buprenorphine-induced respiratory depression in mice. Presented at American Physiological Society: Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender; 2015 Nov 17-20; Annapolis, MD.

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