Co-Director of Anesthesiology Research
Anesthesia Research Division
Neurochemical regulation of sleep and wakefulness, mechanisms of general anesthesia, mechanisms underlying the relationship between sleep disruption and psychiatric disorders.
My research program aims to identify the neurochemical mechanisms and brain regions that regulate behavioral states such as sleep, wakefulness, and anesthesia. The goals of my laboratory are to identify overlapping neuronal circuits regulating the interactions between sleep, anesthesia, mood, cognition, and pain. The work focuses on acetylcholine, GABA, and hypocretin/orexin as neurotransmitters, and the pontine reticular formation, basal forebrain, and prefrontal cortex as brain regions important for behavioral state control.
Lydic R, Keifer JC, Baghdoyan HA, Craft R, Angel C. Principles and Practice of Sleep Medicine, 6th Edition. New York: Elsevier; c2016. Chapter 24, Opiate action on sleep and breathing; p. 260-269.
Lydic RB, Baghdoyan HA. Sleep and Pain. Washington DC: IASP, c2015. Chapter 5, Neurochemical mechanisms mediating opioid-induced REM sleep disruption; p. 101-122.
Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig RR, Shi XY, Lydic R.
RGS proteins and G-alpha-i2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. Sleep. 2016 Feb 1;39(2):393-404. Epub 2015 Nov 6.
Angel CL, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Buprenorphine-induced respiratory depression varies as a function of leptin-related genotype in normal weight and obese mice. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Bourdon AK, Spano G, Bellesi M, Tononi G, Cirelli C, Serra PA, Baghdoyan HA, Lydic R, Campagna SR. Untargeted metabolomics reveal state-dependent neurochemical changes in frontal association (FrA) and motor cortex (M1) of C57Bl/6J (B6) mouse. Presented at Experimental Biology; 2016 Apr 2-6; San Diego, CA.
Angel C, Alami W, Mihalko S, Baghdoyan HA, Lydic R. Sex, leptin status, and obesity modulate buprenorphine-induced respiratory depression in mice. Presented at American Physiological Society: Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender; 2015 Nov 17-20; Annapolis, MD.Top
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